Registration Dossier
Registration Dossier
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EC number: 203-424-6 | CAS number: 106-69-4
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- repeated dose toxicity: dermal
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Abstract
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute subcutaneous toxicity and subacute dermal toxicity studies of hexanetriol and propylene carbonate
- Author:
- Kuramoto M et al.
- Year:
- 1 972
- Bibliographic source:
- Shikoku Med.Jour., 28: 276-283
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Hexane-1,2,6-triol
- EC Number:
- 203-424-6
- EC Name:
- Hexane-1,2,6-triol
- Cas Number:
- 106-69-4
- Molecular formula:
- C6H14O3
- IUPAC Name:
- hexane-1,2,6-triol
- Test material form:
- liquid
- Details on test material:
- QSAR method by using calculation
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- other: physiological saline
- Duration of treatment / exposure:
- 1 month
- Frequency of treatment:
- daily
Doses / concentrationsopen allclose all
- Dose / conc.:
- 5 other: %
- Dose / conc.:
- 15 other: %
- Dose / conc.:
- 25 other: %
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 25 other: %
- Based on:
- test mat.
- Sex:
- not specified
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Increase of basal celles, keratinization, hyperkeratosis were observed histologically on the applied area in a few cases. However, there was no obvious difference in weight gain, food and water intake, urinalysis, plasma analysis, hematology and weight of organs as compared to the controls.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
