Registration Dossier
Registration Dossier
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EC number: 203-424-6 | CAS number: 106-69-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26.01.1989 to 20.02.1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EEC Guideline 84/449/EEC
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Hexane-1,2,6-triol
- EC Number:
- 203-424-6
- EC Name:
- Hexane-1,2,6-triol
- Cas Number:
- 106-69-4
- Molecular formula:
- C6H14O3
- IUPAC Name:
- hexane-1,2,6-triol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: White russian (Albino)
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS:
- Strain: Rabbit / White Russian
- Breeder: ASTA Pharma AG, D-4800 Bielefeld 14
- Number and sex: 3 animals (2 males and 1 females)
- Body weigth: males 2.43 or 2.54 kg, female 3.05 kg
- Age: 11 month
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS:
- Diet: Standard diet, ssniff K, "Special Diet for Rabbits" supplied by ssniff Spezialfutter GmbH, D-4770 Soestad libitum
- Water: tab water ad libitum
- Housing individually in stainless steel cages
- Temperature: 21-22°C
- Rel. Humidity: 45-60%
- Light/dark period: 12/12h
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 4 hours (occlusive patch)
- Observation period:
- Observation Times: 1, 24, 48 and 72 hours after removal of the patches
Duration of the Observation Period: 3 days p. appl. - Number of animals:
- 2 males and 1 female
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
Any other information on results incl. tables
Systemic-toxic effects did not occur after dermal application of the test substance. The general condition of the test animals was not affected.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Following 4-hour occlusive treatment with 0.5 mL undiluted test item to the intact skins of three rabbits no signs of irritation were oberved. Neither erythema nor edema could be detected during the observation period. Thus, 1,2,6-Hexantriol is considered to be non-irritant in this test system, and according to Regulation (EC) 1272/2008 the data are conclusive but not sufficient for classification.
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