Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was conducted on15 March 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Remarks:
- Study was not conducted under a specific Good Laboratory Practices (GLP) program, this study was conducted following the principles of GLP by experienced and trained personnel using calibrated standards and instrumentation. Relevant SOPs were followed.
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Lot/Batch number: 1004R18708
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 1 - < 1.5
- Temp.:
- 20 °C
- pH:
- > 6.2 - < 6.5
- Details on results:
- The mean log Pow for RD14156 is 1.2.
- Conclusions:
- The mean log Pow of RD14156, over six determinations, is 1.2.
- Executive summary:
The RD14156 material under test was analyzed per guidelines as set forth in OECD 107, partition coefficient, shake flask method. The mean log Pow for RD14156 is 1.2.
Reference
Mass balance and octanol/water ratio for RD14156.
| Run # | RD 14156 added | RD 14156 dissolved | Ratio octanol/water | Log octanol/water |
| 1A | 0.507 | 0.217 | 15.7 | 1.2 |
| 1B | 0.503 | 0.235 | 22.3 | 1.3 |
| 2A | 0.504 | 0.249 | 9.61 | 1.0 |
| 2B | 0.504 | 0.245 | 10.9 | 1.0 |
| 3A | 0.533 | 0.250 | 29.2 | 1.5 |
| 3C | 0.509 | 0.216 | 25.6 | 1.4 |
| Mean | 18.9 | 1.24 | ||
| Std Devn. | 8.05 | 0.20 |
Description of key information
The RD14156 material under test was analyzed per guidelines as set forth in OECD 107, partition coefficient, shake flask method. The mean log Pow for RD14153 is 1.2.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.2
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
