RD 14156

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

The study was conducted on15 March 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

not specified

GLP compliance:

no

Remarks:

Study was not conducted under a specific Good Laboratory Practices (GLP) program, this study was conducted following the principles of GLP by experienced and trained personnel using calibrated standards and instrumentation. Relevant SOPs were followed

Type of method:

flask method

Specific details on test material used for the study:

Lot/Batch number: 1004R18708

Key result

Water solubility:

> 0.239 - < 0.34 g/L

Conc. based on:

test mat.

Loading of aqueous phase:

1 g/L

Incubation duration:

> 1 - < 3 d

Temp.:

30 °C

pH:

> 5.4 - < 5.6

Details on results:

The aqueous concentrations determined for RD14156 in the equilibrated samples are shown in Table1. Only determinations 3, 4, 5 and 6 are within 15% of the average value, determinations 1 and 2 are outside. The amount of sample initially added to the tubes is also indicated. The averaged water solubility for RD14156 is [0.26 g/L].

The aqueous concentrations determined for RD14156 in the equilibrated samples are shown in Table 1. Only determinations 3, 4, 5 and 6 are within 15% of the average value, determinations 1 and 2 are outside. The amount of sample initially added to the tubes is also indicated. The averaged water solubility for RD14156 is [0.26 g/L].

Table 1. RD1416 water solubility.

Sample #	Sample added (g/L)	Equilibration time (days)	Measured conc. (g/L)	Percent of average
1	1.136	1	0.327	128
2	1.110	1	0.340	133
3	1.068	2	0.273	107
4	1.034	2	0.270	106
5	1.142	3	0.241	94
6	1.064	3	0.239	93
Average of samples 3 - 6			0.256	-

Conclusions:

The RD14156 material under test was analyzed per guidelines as set forth in OECD 105, water solubility, shake flask method. The water solubility is 0.26 [g/L].

Executive summary:

The RD14156 material under test was analyzed per guidelines as set forth in OECD 105, water solubility, shake flask method. size exclusion chromatography (SEC) was the method of choice to determine concentrations of test material in solutions. The water solubility is 0.26 [g/L].

Description of key information

The RD 14156 material under test was analyzed in accordance with the guideline set forth in OECD 105, water solubility, shake flask method. the water solubility was 0.26 g/L

Key value for chemical safety assessment

Water solubility:

0.26 g/L

at the temperature of:

30 °C