Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 234-201-1 | CAS number: 10595-06-9
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No toxicokinetic data is available on either the target substance or the source substance.
As no specific data for the absorption rate from the oral, the dermal or the inhalational route of exposure is available, default assumption will be applied. Thus, absorption from the dermal and the oral route is considered to be the same. For extrapolation from oral exposure to inhalation exposure the absorption by inhalation is assumed to be a factor 2 higher.
No data is available on either the target substance or the source substance.
Non-specific esterase activity in the gastrointestinal tract (including from gastrointestinal microorganisms) and in liver and plasma may result in hydrolysis of 2-phenoxyethyl methacrylate into 2-phenoxyethanol and methacrylate/ methacrylic acid. No specific data as to the extent and rate of this type of metabolism is available but it may be anticipated that the unspecific esterase activity may be rather similar for the target as well as for the source substance (2 -phenoxyethyl acrylate) from which read-across in relation to toxicity is made.
See read-across justification attached in section 13
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 50
- Absorption rate - inhalation (%):
- 100
Additional information
Based on read-across the structure of 2-phenoxyethyl acrylate, no/low bioaccumulation is expected for 2 -phenoxyethyl methacrylate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
