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EC number: 234-201-1 | CAS number: 10595-06-9
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study followed the guideline; DIN 38412-9 (1989-05) German Standard Methods For Examination Of Water, Waste Water & Sludge; Bio Assays (group L); Determination Of Inhibitory Effects Of Water Constituents On The Growth Of Scenedesmus Green Algae (l9)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- ISO 8692 (Water Quality - Fresh Water Algal Growth Inhibition Test with Scenedesmus subspicatus and Selenastrum capricornutum)
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 38412 L9
- GLP compliance:
- not specified
- Details on sampling:
- samples analyzed at 0h, 24h, 48h 72h and 96h.
- Details on test solutions:
- Concentration range; 0.5 mg/l to 25 mg/l.
No other vehicle than water.
water solubility in stock solution 40 g/l - Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Details on test organisms:
- Obtained from Algensammlung Göttingen SAG 86.81
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 21 C (+/- 2oC)
- pH:
- 7.25-7.98
- Nominal and measured concentrations:
- Nominal concentrations; 0.5-25 mg/l
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- 0.71 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 0.19-2.61
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 4.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 1.87-10.3
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- 0.11 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: 0.03-0.38
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: 1.02-2.84
- Duration:
- 96 h
- Dose descriptor:
- EC10
- Effect conc.:
- 0.42 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 0.23-0.76
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 4.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 2.98-5.66
- Duration:
- 96 h
- Dose descriptor:
- EC10
- Effect conc.:
- 0.14 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: 0.04-0.43
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.33 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: 0.77-2.28
- Executive summary:
EC10 and EC50 values for the toxicity of phenoxyethylacrylate to the freshwater greenalgae Desmodesmus subcapitatus was established at 72 and 96h hours, both in terms of biomass and growth rate. The testsytem was equal to ISO 8692 and a positive control ensured that the system was valid. EC 10 (96h) were 0.14 and 0.42 mg/l, and EC 50 (96h) were 1.33 and 4.1, when based on biomass and growth rate, respectively. EC10 (72 h) was 0.71 based on growth rate and EC50 (72 h) was 4.44 based on growth rate.
No data on marine algae have been identified.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Read-across from toxicity study on aquatic algae one closely structural and physicochemical related substance: 2-Phenoxyethyl acrylate (M140).
For further read-across justification se document attached in section 13. - Reason / purpose for cross-reference:
- read-across source
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- 0.71 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 0.19-2.61
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 4.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 1.87-10.3
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- 0.11 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: 0.03-0.38
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: 1.02-2.84
- Duration:
- 96 h
- Dose descriptor:
- EC10
- Effect conc.:
- 0.42 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 0.23-0.76
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 4.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 2.98-5.66
- Duration:
- 96 h
- Dose descriptor:
- EC10
- Effect conc.:
- 0.14 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: 0.04-0.43
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.33 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: 0.77-2.28
- Executive summary:
No data is available for 2-Phenoxyethyl methacrylate (T).
Toxicity of 2-phenoxyethyl acrylate to the freshwater green algae Desmodesmus subcapitatus was tested according to a test guideline equal to ISO 8692 and a positive control ensured that the system was valid.EC 10 (96h) were 0.14 and 0.42 mg/l, and EC 50 (96h) were 1.33 and 4.1, when based on biomass and growth rate, respectively. EC10 (72 h) was 0.71 based on growth rate and EC50 (72 h) was 4.44 based on growth rate.
Due to structural and pysico-chemical similarity to 2-Phenoxyethyl methacrylate, equal EC 10 (72h and 96h) and EC50 (72h and 96h) can also be concluded for 2-Phenoxyethyl methacrylate as well.
See justification for read-across attached in section 13.
Referenceopen allclose all
Description of key information
Based on a read-across to the measured toxicity to algae of the source substance, ErC50 and ErC10 to aquatic algae and cyanobacteria is derived at:
ErC50: 4.44 mg/L (Desmodesmus subcapitatus. 72hr)
ErC10: 0.71 (Desmodesmus subcapitatus. 72hr)
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 4.44 mg/L
- EC10 or NOEC for freshwater algae:
- 0.71 mg/L
Additional information
EC10 and EC50 values for the toxicity of 2-phenoxyethyl acrylate (S) to the freshwater greenalgae Desmodesmus subcapitatus was established at 72 and 96h hours, both in terms of biomass and growth rate. The testsytem was equal to ISO 8692 and a positive control ensured that the system was valid. EC 10 (96h) were 0.14 and 0.42 mg/l, and EC 50 (96h) were 1.33 and 4.1, when based on biomass and growth rate, respectively. EC10 (72 h) was 0.71 based on growth rate and EC50 (72 h) was 4.44 based on growth rate.
Due to structural and pysico-chemical similarity to 2-Phenoxyethyl methacrylate, the same EC10 (72h and 96h) and EC50 (72h and 96h) can also be concluded for 2-Phenoxyethyl methacrylate as well.
See justification for read-across attached in section 13.
No data on marine algae have been identified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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