Registration Dossier
Registration Dossier
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EC number: 943-697-5 | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- - Principle of test: single application of test substance onto the eye of rabbits.
- Parameters analysed / observed: oedema, redness. - GLP compliance:
- no
- Remarks:
- Pre 1981
Test material
- Reference substance name:
- 5-(diisopropylamino)-2-[[4-(dimethylamino)phenyl]azo]-3-methyl-1,3,4-thiadiazolium trichlorozincate(1-)
- EC Number:
- 298-265-2
- EC Name:
- 5-(diisopropylamino)-2-[[4-(dimethylamino)phenyl]azo]-3-methyl-1,3,4-thiadiazolium trichlorozincate(1-)
- Cas Number:
- 93783-70-1
- Molecular formula:
- C17H27N6S.Cl3Zn
- IUPAC Name:
- 5(E)-5-(diisopropylamino)-2-((4-dimethylamino)phenyl)diazenyl)-3-methyl-1,3,4-thiadiazol-3-ium trichlorozincate(1-)
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent negative control
- Amount / concentration applied:
- 50 mg
- Observation period (in vivo):
- after 10 minutes, 1 and 24 hours and 3 and 8 days.
- Details on study design:
- - Washing: within 24 hours.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other:
- Remarks:
- conjunctivae irritation
- Time point:
- 24 h
- Reversibility:
- fully reversible within: 3 days
- Remarks on result:
- no indication of irritation
- Remarks:
- slightly redness and oedema observed
- Irritation parameter:
- cornea opacity score
- Basis:
- animal:
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- iris score
- Basis:
- animal:
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- conjunctivae score
- Basis:
- animal:
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- chemosis score
- Basis:
- animal:
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritant
- Conclusions:
- Not irritating.
- Executive summary:
Rabbits were exposure to the test substance in its unchanged form (powder). The scoring was performed at 10 minutes, 1 and 24 hours and after 3 and 8 days.
After 1 hour, slight oedema and redness were noted; at 24 hours only a slight redness persisted; at 8 days no signs of irritation were present. In addition, since the substance was not washed away from the eyes of rabbits, the results of the test could have been subjected to overestimation, due to the intrinsic irritative nature of dusty materials.
Conclusion
Not eye irritant.
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