Registration Dossier
Registration Dossier
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EC number: 943-697-5 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- The test was conducted by means of Read Across approach. Further information was attached at section 13
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- - Principle of test: single oral administration
- Observation period: 7 days
- Parameters analysed / observed: mortality - GLP compliance:
- no
- Remarks:
- Pre 1981
Test material
- Reference substance name:
- Similar Substance 01 - ABr165:1
- IUPAC Name:
- Similar Substance 01 - ABr165:1
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- - Concentration in vehicle: 3 to 35 % suspension in 0.5 % CMC solution.
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed.
- Clinical signs:
- other: Dyspnea, feces blackened, some animals showed diarrhea and slight apathy.
- Gross pathology:
- No abnormalities detected.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP Criteria not met
- Conclusions:
- LD50 > 10000 mg/kg b.w.
- Executive summary:
Rats were exposed to a single oral dose of the test item, which followed a period of observation of 7 days.
No mortality was recorded; no significant clinical signs or organ abnormalities were recorded.
Conclusion
LD50 > 10000 mg/kg b.w.
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