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EC number: 207-395-0 | CAS number: 467-62-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Toxicity to aquatic invertebrates:
Based on the prediction done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the seven closest read across substances, toxicity on Daphnia magna predicted for 4,4',4''-Triaminotrityl alcohol (467-62-9).The EC50 value was estimated to be 225 mg/l when4,4',4''-Triaminotrityl alcohol exposed to Daphnia magna for 48 hrs.
Short term toxicity to aquatic algae and cyanobacteria:
Based on the prediction done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the six closest read across substances, toxicity on Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) predicted for 4,4',4''-Triaminotrityl alcohol (467-62-9).The EC50 value was estimated to be 107.48 mg/l when4,4',4''-Triaminotrityl alcohol (467-62-9)exposed to Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)for 72 hrs.
Additional information
Summarized results of toxic effect of the chemical 4,4',4''-Triaminotrityl alcohol (467-62-9) on the growth and other normal activities of aquatic life, by the collection of data from various databases, experimental and predicting reports, the effects of chemical on the basis of structure and functional similarities.
Toxicity to aquatic invertebrates:
Toxicity of chemical 4,4',4''-Triaminotrityl alcohol on the growth of aquatic life’s have been studied and concluded the nature and classification category on the basis of data obtain from various sources, RA chemicals and also from predicted QSAR reports which support the classification of the target chemical.
In the first weight of evidence study for 4,4',4''-Triaminotrityl alcohol(467-62-9) from QSAR toolbox version 3.4, 2017, Based on the prediction done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the seven closest read across substances, toxicity on Daphnia magna predicted for 4,4',4''-Triaminotrityl alcohol (467-62-9).The EC50 value was estimated to be 225 mg/l when4,4',4''-Triaminotrityl alcohol exposed to Daphnia magna for 48 hrs.
Similarly in the another weight of evidence study for 4,4',4''-Triaminotrityl alcohol(467-62-9) from EPI suite 2017, Based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted. On the basis of this program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be 296.457 mg/l for Tris(p-aminophenyl) methanol in 48 hrs. Based on this value it can be concluded that the substance Tris(p-aminophenyl)methanol is considered to be not toxic to aquatic environment and cannot be classified in aquatic acute 1/chronic 1/chronic 2/chronic 3 category as per the criteria mentioned in CLP regulation.
Similarly in the third weight of evidence study for RA chemical (112-11-2), ecotoxicology. Study was conducted to determine the toxicity of chemical Sulfadimethoxine on the mobility of daphnia magna for 48hrs of exposure with chemical. Test was performed according to the U.S. Environmental Protection Agency guideline. Effect concentration of chemical on Freshwater daphnia was tested by static system. Different measured concentration was prepared by dissolving the Sulfadimethoxine with solvent carrier, 0.5% of dimethylsulphoxide (DMSO). Daphnia fed daily during the test. All water parameters measured daily. Immobilization was employed as an endpoint and considered to happen if no movement was detected for 15 s after gentle shaking of the test vehicle. Immobilization measured by probit analysis. Based on the immobilization of daphnia magna due to the exposure of chemical Sulfadimethoxine, the EC50 was 639.8 mg/l with 95 % CI was 396.10-883.5 MG/L for 24hrs exposure and 248 mg/l with 95 % CI was 199.20-296.8 mg/l for 48hrs. Thus it was concluded that the chemical was nontoxic and can be consider to be not classified as toxic to aquatic environment as per the CLP classification criteria.
Similarly in the fourth weight of evidence study for RA chemical 2-Amino-9,10-anthracenedion (117-79-3) Study was conducted to determine the toxicity of chemical 2-Amino-9,10-anthracenedion on the mobility of daphnia magna for 24hrs of exposure with chemical. Test was performed in the static system in which <24 h old Daphnis were used. After the exposure, based on the immobilization of daphnia magna due to the exposure of chemical 2-Amino-9,10-anthracenedion (2-amino-9,10-dihydroanthracene -9,10-dione), the EC50 was 278 mg/l after 24hrs exposure with chemical. Thus it was concluded that the chemical was nontoxic and can be consider to be not classified as toxic to aquatic environment as per the CLP classification criteria.
Thus based on the data available for 4,4',4''-Triaminotrityl alcohol(467-62-9), from various data sources ecotox, EPIsuite, publications and QSAR toolbox version 3.4, 4,4',4''-Triaminotrityl alcoholwas consider to be nontoxic and thus can be consider to be not classified as per the CLP classification criteria.
Toxicity to aquatic algae and cyanobacteria:
Toxicity of chemical 4,4',4''-Triaminotrityl alcohol on the growth of aquatic life’s have been studied and concluded the nature and classification category on the basis of data obtain from various sources, RA chemicals and also from predicted QSAR reports which support the classification of the target chemical.
In the first weight of evidence study for 4,4',4''-Triaminotrityl alcohol(467-62-9) from QSAR toolbox version 3.4, 2017, Based on the prediction done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the six closest read across substances, toxicity on Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) predicted for 4,4',4''-Triaminotrityl alcohol (467-62-9).The EC50 value was estimated to be 107.48 mg/l when4,4',4''-Triaminotrityl alcohol (467-62-9)exposed to Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)for 72 hrs.
Similarly in the another weight of evidence study for 4,4',4''-Triaminotrityl alcohol(467-62-9) from EPI suite 2017, Based on the prediction done using the EPI Suite ECOSAR version 1.11, the short term toxicity on green algae was predicted for test substance Tris(p-aminophenyl) methanol. On the basis of effects observed in a static freshwater system, the effect concentration EC50 value of the substance is estimated to be191.688 mg/l for green algae for 96 hrs.. Based on this value, it can be concluded that the test chemical Tris(p-aminophenyl)methanol can be considered as non-toxic to green algae at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria.
Similarly in the third weight of evidence study for RA chemical (106-47-8), ecotox databases 2017, Study was conducted to determine the toxicity of chemical 4-Chloroaniline on the growth of daphnia magna. Test was performed in the static system for a very short period (>=49 - <=79) Minute(s). After the exposure no effect was observed on the photosynthesis rate of green algae. Based on the Photosynthesis reduction of green algae (Scenedesmus Subspicatus) due to the exposure of chemical 4-Chloroaniline, the NOEC was 250 mg/l. Thus it was concluded that the chemical was nontoxic and can be consider to be not classified as toxic to aquatic environment as per the CLP classification criteria.
Thus based on the data available for toxicity to invertebrates and algae of 4,4',4''-Triaminotrityl alcohol (467-62-9), from various data sources ecotox, EPIsuite, databases publications, and QSAR toolbox version 3.4, 4,4',4''-Triaminotrityl alcohol was consider to be nontoxic and thus can be consider to be not classified as per the CLP classification criteria.
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