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EC number: 204-541-5 | CAS number: 122-40-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer-reviewed journal
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Monographs on fragrance raw materials: Amyl cinnamic aldehyde
- Author:
- D.L.J.Opdyke
- Year:
- 1 973
- Bibliographic source:
- Food and Cosmetics Toxicology Volume 11, Issue 5, October 1973, Pages 855-856
- Reference Type:
- secondary source
- Title:
- Initial Risk-Based Prioritization of High Production Volume (HPV) Chemicals Cinnamyl Derivatives Category.
- Author:
- U. S. Environmental Protection Agency (EPA) Office of Pollution Prevention and Toxics (OPPT) Risk Assessment Division (RAD)
- Year:
- 2 009
- Bibliographic source:
- U.S. Environmental Protection Agency Risk-Based Prioritization Document, April 2009.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: refer below
- Principles of method if other than guideline:
- The acute toxicity study was examined to evaluate the toxic effects of administration of amyl cinnamic aldehyde (2-benzylideneheptanal) (CAS No. 122-40-7) in rabbit by the dermal route.
- GLP compliance:
- not specified
- Test type:
- other: No data available
- Limit test:
- no
Test material
- Reference substance name:
- 2-benzylideneheptanal
- EC Number:
- 204-541-5
- EC Name:
- 2-benzylideneheptanal
- Cas Number:
- 122-40-7
- Molecular formula:
- C14H18O
- IUPAC Name:
- 2-benzylideneheptanal
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): amylcinnamaldehyde
- Molecular formula : C14H18O
- Molecular weight: 202.2952 g/mol
- Smiles notation: c1(\C=C(\CCCCC)C=O)ccccc1
- InChl: 1S/C14H18O/c1-2-3-5-10-14(12-15)11-13-8-6-4-7-9-13/h4,6-9,11-12H,2-3,5,10H2,1H3/b14-11-
- Substance type: organic
- Physical state: Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Amyl cinnamic aldehyde (2-benzylideneheptanal)
- Molecular formula: C14H18O
- Molecular weight : 202.2952 g/mole
- Substance type: Organic
- Physical state:Liquid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data available
- Females (if applicable) nulliparous and non-pregnant: No data available
- Age at study initiation: No data available
- Weight at study initiation: No data available
- Fasting period before study: No data available
- Housing: No data available
- Diet (e.g. ad libitum): No data available
- Water (e.g. ad libitum): No data available
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%): No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available
IN-LIFE DATES: From: To: No data available
Administration / exposure
- Type of coverage:
- other: dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- No data available
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 4 rabbits/sex
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: No data available
- Frequency of observations and weighing: No data available
- Necropsy of survivors performed: No data available
- Other examinations performed: No data available - Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: There was no evidence of toxicity at the dose tested.
- Mortality:
- No mortality observed upto 2000.0 mg/kg bw
- Clinical signs:
- other: There was no evidence of toxicity at the dose tested.
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified based on CLP criteria
- Conclusions:
- The acute dermal median lethal dose (LD50) was considered to be greater than 2000 mg/kg bw (>2000 mg/kg bw). When rabbits were treated with amyl cinnamic aldehyde (2-benzylideneheptanal) (CAS No. 122-40-7) by dermal application.
- Executive summary:
The acute toxicity study was examined to evaluate the toxic effects of administration of amyl cinnamic aldehyde (2-benzylideneheptanal) (CAS No. 122-40-7) in rabbit by the dermal route. Four rabbits were administered amyl cinnamic aldehyde (2-benzylideneheptanal) dermally at 2000 mg/kg bw. No evidence of toxicity was seen. No mortality was observed. hence the acute dermal median lethal dose (LD50) was considered to be greater than 2000 mg/kg bw (>2000 mg/kg bw). When rabbits were treated with amyl cinnamic aldehyde (2-benzylideneheptanal) (CAS No. 122-40-7) by dermal application.
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