Registration Dossier
Registration Dossier
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EC number: 203-678-8 | CAS number: 109-53-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
- Principles of method if other than guideline:
- LD50 in mice after i.p. injection
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Isobutyl vinyl ether
- EC Number:
- 203-678-8
- EC Name:
- Isobutyl vinyl ether
- Cas Number:
- 109-53-5
- Molecular formula:
- C6H12O
- IUPAC Name:
- 1-(ethenyloxy)-2-methylpropane
- Details on test material:
- no details
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on exposure:
- aqueous emulsion with CNC
- Doses:
- 200, 1600, 2000, 2500, 3200, and 6400 µl/kg bw.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Observation: Observation period: 7 days. Clinical signs of toxicity, mortalities within 7 days. Terminal necropsy.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 150 mg/kg bw
- Remarks on result:
- other: for males and females combined
Any other information on results incl. tables
Mice died within 2 days. Mortality in males and females very similar. No mortality at <=2000 µl/kg bw.
Clinical signs: dyspnoea, convulsions, staggered gait, apathy, prone position.
No clinical effects after 7 days.
Necropsy: no effects.
Applicant's summary and conclusion
- Conclusions:
- LD50 in male & female mice after i.p. injection was 2150 mg/kg bw.
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