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Diss Factsheets
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EC number: 201-029-3 | CAS number: 77-47-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 305 (Bioconcentration: Flow-through Fish Test)
- Deviations:
- yes
- Remarks:
- No depuration phase, no sample of fish until the end of the uptake phase
- GLP compliance:
- no
- Radiolabelling:
- no
- Details on sampling:
- - Sampling intervals/frequency for test organisms: End of the study
- Sampling intervals/frequency for test medium samples: Daily - Vehicle:
- not specified
- Details on preparation of test solutions, spiked fish food or sediment:
- PREPARATION OF SPIKED FISH FOOD
- Details on fish food (source, fat content as supplied, etc): brine shrimp nauplii 3 to 4 times a day - Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- TEST ORGANISM
- Common name: Fathead minnow
- Strain: Pimephales promelas
- Age at study initiation: 1 day - Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 30 d
- Hardness:
- 45 to 47 mg/l (CaCO3)
- Test temperature:
- 25°C +/- 2°C
- pH:
- 7.2 to 7.7
- Dissolved oxygen:
- 7.2 to 8.6 mg/l
- Details on test conditions:
- TEST SYSTEM
- Test vessel: aquarium
- Type (delete if not applicable): open / closed
- Material, size, headspace, fill volume: glass, 45x16x18 cm, 8.9 l
- No. of organisms per vessel: 25
- Renewal rate of test solution (frequency/flow rate): 500 ml / 3 min
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Unfiltered Lake Superior water
OTHER TEST CONDITIONS
- Photoperiod: 16 h
- Light intensity: 18-28 lumens - Nominal and measured concentrations:
- 7.3, 38.4, and 40.0 µg/l
- Reference substance (positive control):
- no
- Details on estimation of bioconcentration:
- At the end of the study whole fish were analyzed for residues using the methods described by Veith et al (1971).
- Conc. / dose:
- 7.3 µg/L
- Temp.:
- >= 23 - <= 27 °C
- pH:
- 7.5
- Type:
- BCF
- Value:
- < 11 dimensionless
- Basis:
- whole body w.w.
- Conc. / dose:
- 38.4 µg/L
- Temp.:
- >= 23 - <= 27 °C
- pH:
- 7.5
- Type:
- BCF
- Value:
- < 11 dimensionless
- Basis:
- whole body w.w.
- Key result
- Conc. / dose:
- 40 µg/L
- Temp.:
- >= 23 - <= 27 °C
- pH:
- 7.5
- Type:
- BCF
- Value:
- < 11 dimensionless
- Basis:
- whole body w.w.
- Details on results:
- - Mortality of test organisms: LC50 (30 days) = 6.7 µg/l
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Residues of the test substance in 30 day-old fathead minnows were less than 0.1 µg/g in all tanks. As a result the BCF was < 11 for all concentrations.
- Executive summary:
The bioaccumulation of hexachlorocyclopentadiene to fish was determined using a method similar to the OECD Guideline for Testing of Chemicals 305 (non GLP) with deviations. The absence of the depuration phase is not considered as significant considering that the BCF is less than 11.
The study was carried out on Pimephales promelas. The animals were exposed to concentrations of 7.3, 38.4, or 40.0 µg/l for 30 days under flow-through conditions. At the end of the study, they were analysed for residues of the substance.
Residues of the test substance in 30 day-old fathead minnows were less than 0.1 µg/g in all tanks. As a result the BCF was < 11 for all concentrations.
Reference
Residues of the test substance in 30 day-old fathead minnows were less than 0.1 µg/g in all tanks. As a result the BCF was < 11 for all concentrations.
Description of key information
The bioaccumulation of Hexachlorocyclopentadiene in fish was determined using a method similar to the OECD Guideline for Testing of Chemicals 305 (non GLP). The absence of the depuration phase was not considered as significant considering that the BCF was less than 11.
The study was carried out onPimephales promelas (fathead minnow). The animals were exposed to concentrations of 7.3, 38.4 or 40.0 µg/l for 30 days under flow-through conditions. At the end of the study, they were analysed for residues of the substance.
Residues of the test substance in 30 day-old fathead minnows were less than 0.1 µg/g in all tanks. As a result the BCF was < 11 for all tested concentrations.
Key value for chemical safety assessment
- BCF (aquatic species):
- 11 dimensionless
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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