Registration Dossier
Registration Dossier
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EC number: 204-259-2 | CAS number: 118-55-8
Toxicity to reproduction
Administrative data
- Endpoint:
- reproductive toxicity, other
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- secondary source
- Title:
- REPROTOX - PHENYL SALICYLATE
- Author:
- Truven Health Analytics Inc.
- Year:
- 2 013
- Bibliographic source:
- MICROMEDEX(R) Healthcare Series Vol. 157
Materials and methods
Results and discussion
Any other information on results incl. tables
Phenyl salicylate (Salol) is the phenyl ester of 2-hydroxybenzoic acid, used as an analgesic and in chemical manufacture. This agent was reported to be teratogenic in rats at an unspecified exposure level (1). We have been unable to locate references on possible human reproductive or lactation
effects of this compound.
Selected References
1. Nagahama M, Akiyama N, Miki T: Experimental production of malformations with salicylates (acetyl salicylate and phenyl salicylate) in rats. Congenital Anom 5:35, 1965; cited in Schardein JL, Chemically Induced Birth Defects, New York, Marcel Dekker, 3rd ed., 2000, p.148.
Applicant's summary and conclusion
- Conclusions:
- Phenyl salicylate was reported to be teratogenic in rats at an unspecified exposure level. We have been unable to locate references on possible human reproductive or lactation effects of this compound.
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