Registration Dossier
Registration Dossier
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EC number: 204-259-2 | CAS number: 118-55-8
Endpoint summary
Administrative data
Description of key information
Acute aquatic toxicity
Fish, Ictalurus punctatus, LC50 = 1.250 mg/L.
Fish, Pimephales promelas, LC50 = 1.09 mg/L.
Acute aquatic toxicity is normally determined using a fish 96-hour LC50 , a crustacea species 48-hour EC50 and/or an algal species 72- or 96-hour EC50. These species cover a range of trophic levels and taxa and are considered as surrogate for all aquatic organisms. For phenyl salicylate are only available LC50 on fish.
Overall, available data are inconclusive since ecotoxicological data are not available for crustacea species and algal species an data on fish are just over 1 mg/L.
Chronic aquatic toxicity
Chronic aquatic toxicity data are not available. Acute aquatic toxity data are available for fish:
Fish, Ictalurus punctatus, LC50 = 1.250 mg/L.
Fish, Pimephales promelas, LC50 = 1.09 mg/L.
Biodegradability data are not available. In accordance with Guidance on the Application of the CLP Criteria (version 5.0), in general, no quantitative estimation method (QSAR) for estimating the degree of biodegradability of organic substances is yet sufficiently accurate to unequivocally predict rapid degradation. However, results from such methods may be used to predict that a substance is not rapidly degradable, or be used in a Weight of Evidence approach.
In general, a QSAR prediction that the substance is not rapidly degradable is considered a better documentation for classification than application of a default classification, when no useful degradation data are available.
The biodegradability of Phenyl salicylate has been predicted using START (Structural Alerts for Reactivity in Toxtree) biodegradation and persistence plug-in, which is based on a compilation of structural alerts for environmental persistence and biodegradability. These structural alerts are molecular functional groups or substructures that are known to be linked to the environmental persistence or biodegradability of chemicals. As a result, Phenyl salicylate has been predicted as Class 2 (persistent chemical).
Experimental BCF value is not available and logKow has not been determined. Predicted (KOWWIN Program (v1.68)) logKow is 3.82.
Overall, since (i) the acute toxicity value on fish range form 1-10 mg/L, (ii) the substance cannot be considered as biodegradable and (ii) predicted logkow is close to 4, the substance is classified as Aquatic Chronic H411.
Additional information
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