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Physical & Chemical properties

Density

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Reference
Endpoint:
density, other
Remarks:
density
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental result performed using standard methods of analysis.
Qualifier:
according to
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
Principles of method if other than guideline:
The Pour density and tapped density of powders” was determined by method as recommended in The International Pharmacopoeia, Fourth Edition, 2014
GLP compliance:
not specified
Type of method:
other: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014
Specific details on test material used for the study:
Name of the test chemical: Tetraethylammonium chloride
Molecular formula:C8H20ClN
Molecular weight: 165.706 g/mol
Smiles Notation: [N+](CC)(CC)(CC)CC.[ClH-]
InChI: 1S/C8H20N.ClH/c1-5-9(6-2,7-3)8-4;/h5-8H2,1-4H3;1H/q+1;/p-1
Substance Type: Organic
Physical State: Hygroscopic white Powder
Key result
Type:
pour density
Density:
0.607 g/cm³
Temp.:
25.2 °C
Remarks on result:
other: at 965.2 hPa pressure
Key result
Type:
tap density
Density:
0.667 g/cm³
Temp.:
25.2 °C
Remarks on result:
other: at 965.2 hPa pressure

TEST ITEM DESCRIPTION AND RESULTS

FOR SOLIDS:

By Pour Density and Tapped Density Method:

Method Details

Observations

Remarks if, any

Guideline

OECD 109

1st

Reading

2nd Reading

 

 

Method

Test methods: Pour density

and tapped density of

powders”recommended in

The International

Pharmacopoeia, Fourth

Edition, 2014

 

 

Principle of method

Pour Density:It is the ratio

of known weight of test item

and its volume in graduated

glass cylinder.

Tap Density:It is the

difference between the

volume of test item

measured before & after

tapping in the graduated

glass cylinder.

 

 

Test temperature (°C)

-

25.0°C

25.5°C

Atmospheric

pressure (in hPa)

-

963.8

966.7

Weight of test

item(m)

 

 

20.020

20.020

Volume of measuring cylinder; readability in g

 

50ml; 1 ml

50 ml; 1 ml

Volume of test item

without tapping (V)

 

32

34

Volume of test item

after tapping ( V1)

After 10 tapping

31

33

 

After 50 tapping

30

30

 

After 100 tapping

30

30

 

After 250 tapping

-

-

 

After 500 tapping

-

-

 

After 750 tapping

-

-

 

 

FOR SOLIDS:

By Pour Density and Tapped Density Method:

Parameters

 

Details

Calculated values

Average

Density

1st

Calculation

2nd

Calculation

Pour Density of test Item (g/cm³)

= m / V

 

0.6256

0.5888

0.6072

Tap density of test Item (g/cm³)

= m / V1

 

0.6673

0.6673

0.6673

 

Conclusions:
The mean pour density and tapped density of Tetraethylammonium chloride (CAS No. 56-34-8) was determined to be 0.6072 g/cm³ and 0.6673 g/cm³ at 25.2°C and 965.2 hPa.
Executive summary:

The density of test item Tetraethylammonium chloride (CAS No. 56-34-8) was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014

using bulk density apparatus. The mean pour density and tapped density of test item was determined to be 0.6072 g/cm³ and 0.6673 g/cm³ at 25.2°C and 965.2 hPa.

Description of key information

The mean pour density and tapped density of Tetraethylammonium chloride (CAS No. 56-34-8) was determined to be 0.6072 g/cm³ and 0.6673 g/cm³ at 25.2°C and 965.2 hPa.

Key value for chemical safety assessment

Additional information

The density of test item Tetraethylammonium chloride (CAS No. 56-34-8) was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014

using bulk density apparatus. The mean pour density and tapped density of test item was determined to be 0.6072 g/cm³ and 0.6673 g/cm³ at 25.2°C and 965.2 hPa.