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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer-review journal

Data source

Reference
Reference Type:
publication
Title:
Tetraethyl ammonium chloride Acute and chronic toxicity in experimental animals.
Author:
O.M .Gruhzit.R.A. Fisken and B.J. Cooper
Year:
1948
Bibliographic source:
Journal of Pharmacology and Experimental Therapeutics. Vol. 92,Pg. 103, 1948

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
other: As mention below
Principles of method if other than guideline:
Acute oral toxicity study of N, N, N-triethylethanaminium chloride was performed in Rat
GLP compliance:
not specified
Test type:
fixed dose procedure
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
- Name of test material (as cited in study report):Tetraethylammonium chloride
- Molecular formula :C8H20N.CI
- Molecular weight :165.706 g/mole
- Substance type:organic
- Physical state:Crystalline powder
- Purity:No data available
- Impurities (identity and concentrations):No data available
Specific details on test material used for the study:
Name of test material (as cited in study report):Tetraethylammonium chloride
- Molecular formula :C8H20N.CI
- Molecular weight :165.706 g/mole
- Substance type:organic
- Physical state:Crystalline powder
-Purity:No data available
- Impurities (identity and concentrations):No data available

Test animals

Species:
rat
Strain:
other: Albino
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
water
Details on oral exposure:
Details on exposure
VEHICLE
- Concentration in vehicle: 40.6% test substance dissolved in distilled water
- Amount of vehicle (if gavage): No data available
- Justification for choice of vehicle: Readily dissolved in water
- Lot/batch no. (if required): No data available
- Purity: No data available

MAXIMUM DOSE VOLUME APPLIED: No data available
DOSAGE PREPARATION (if unusual): No data available
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: No data available
Doses:
2630mg/kg
No. of animals per sex per dose:
155
Control animals:
no
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2 630 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Mortality observed
Mortality:
Mortality observed with 10-30 min due to respiratory failure
Clinical signs:
Tremors ,incoordination ,flaccid prostration
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
LD50 was consiidered to be 2630mg/kg body weight .When albino rats were treated with N, N, N-triethylethanaminium chloride (56-34-8)
Executive summary:

Acute oral toxicity study was done in albino rat using test material N, N, N-triethylethanaminium chloride (56-34-8).155 animals were used. 40.6% test substance dissolved in distilled water to get required dose concentration. Maximum tolerated dose i.e.95-100 % animal survived was determined to be 750.0mg/kg .Clinical signslikeTremors, incoordination, flaccid prostrationwere observed. Mortality observed with 10-30 min due to respiratory failure at dose 2630mg/kg/bw .Hence LD50 was determined2630mg/kg body weight. When albino rats were treated with N, N, N-triethylethanaminium chloride (56-34-8)