2-[3-(4-propyl-heptyl)-morpholin-4-yl]-ethanol hydrochloride

Density

Link to relevant study record(s)

Reference

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

August 10, 2016 - October 21, 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

other:

Version / remarks:

CIPAC MT 3.2

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Deviations:

no

Principles of method if other than guideline:

Methods Description
The pyknometer, together with its glass stopper, was placed into a thermostatically controlled oven at 20°C and - after thermal equilibrium - it was weighed using the analytical balance (W1). The pyknometer was filled with water which had been freshly boiled and cooled, and was placed again in the thermostatic oven at 20°C until thermal equilibrium.
The glass stopper was then fitted to the pyknometer and the exceeding water was removed by adsorbent paper, taking care not to withdraw water from the capillary.
After that, a new thermal equilibrium was reached in the thermostatic oven; the pyknometer was re-weighed (W2); the difference (W2 - W1) was the water equivalent (WE) of the pyknometer at 20°C.
The whole procedure was repeated using the test item saturated solution, obtaining W3 and W4 values; the difference (W3 - W4) was the liquid equivalent (LE) of the pyknometer at 20°C.
The pyknometer was empted, dried and placed again, with its glass stopper, in the thermostatic oven at 20°C until thermal equilibrium; then it was re-weighed (W5). About 5 g of test item were added to the pyknometer, so placed in the oven at 20°C until thermal equilibrium. Finally, it was re-weighed (W6).

A suitable amount of the test item saturated solution, necessary to completely fill the pyknometer was then added, taking care to wet the test item. The pyknometer was placed in the oven at 20°C until thermal equilibrium. Then the glass stopper was fitted to the pyknometer and the exceeding liquid was removed by adsorbent paper, taking care not to withdraw liquid from the capillary.
After a new thermal equilibrium had been reached in the thermostatic oven, the pyknometer was re-weighed (W7).

GLP compliance:

no

Type of method:

pycnometer method

Specific details on test material used for the study:

Internal sample code: 2929564-001
Purity: 100.3% w/w
Batch number: 2510468

Key result

Type:

relative density

Density:

ca. 0.886 other: (g/mL)

Temp.:

20 °C

Results:

Data and results of the tests performed on the test item are reported in Tables 1 and 2.

TABLE 1 Delmopinolo HCl: density. Water equivalent and liquid equivalent

Determination	W1 (g)	W2 (g)	W3 (g)	W4 (g)	WE (g)	LE (g)	S
A	36.4013	86.2862	36.4022	70.5808	49.8849	34.1786	0.6851
B	24.7992	76.9712	24.7987	60.4327	52.1720	35.6340	0.6830
Mean value :							0.6841

 

TABLE 2 Delmopinolo HCl: density. Test item determination

 

Determination	W5 (g)	W6 (g)	W7 (g)	S mean	Density (g/mL)
A	36.4023	38.6012	71.0840	0.6841	0.8854
B	24.7990	26.9742	60.9330	0.6841	0.8867
Mean value :					0.8860
Delta % :					0.14%
Specific gravity (pure number) :					0.8876
Relative density (pure number) :					0.8860

 

Conclusions:

From the experimental data obtained according to the guideline A.3 in Council Regulation (EC) No 440/2008 part A, CIPAC method MT 3.2 and OECD Test No 109, it can be concluded that the density of Delmopinolo HCl sample is 0.8860 g/mL at 20°C; the specific gravity is 0.8876 at 20°C, and the relative density (D204) is 0.8860.

Executive summary:

The density of Delmopinolo HCl sample is 0.8860 g/mL at 20°C.

Description of key information

From the experimental data obtained according to the guideline A.3 in Council Regulation (EC) No 440/2008 part A, CIPAC method MT 3.2 and OECD Test No 109, it can be concluded that the density of Delmopinolo HCl sample is 0.8860 g/mL.

Key value for chemical safety assessment

Relative density at 20C:

0.886