Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-116-0
CAS number: 2156592-45-7
Viability / Mortality:
No deaths occurred during the study period.
No signs of systemic toxicity were observed during the study period. On
application day 2 and 3, the animals treated with test item
concentrations of 5 and 10% showed an erythema of the ear skin (Score
1). On day 4, only the animals of the high dose group showed an erythema
of the ear skin (Score 1).
The body weight of the animals, recorded prior to the first application
and prior to treatment with ³HTdR, was within the range commonly
recorded for animals of this strain and age.
Lymph Node Weights and Cell Counts:
The measured lymph node weights and –cell counts of all animals treated
were recorded after sacrifice. A statistically significant and
biologically relevant increase in lymph node weight and –cell count was
obtained in all test item treated groups in comparison to the
vehicle control group (p<0.05) and a clear dose response was observed.
Furthermore, the cutoff-value for a positive response regarding the
lymph node cell count index of 1.55 reported for BALB/c mice was
exceeded in all dose groups (indices of 2.08, 3.55, and 4.94).
The measured ear weights of all animals treated were recorded after
sacrifice. A statistically significant increase in ear weights was
observed in the high dose group in comparison to the vehicle control
group (p<0.05). Furthermore, for BALB/c mice, a cut off value of 1.1 was
reported for a positive response of the ear weight index regarding ear
skin irritation. None of the indices determined for the test item
treated groups exceeded this threshold.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Šajā tīmekļa vietnē tiek izmantoti sīkfaili, lai nodrošinātu Jums vislabāko lietojumu mūsu tīmekļa vietnēs.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again