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EC number: 261-867-0 | CAS number: 59703-00-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- SIDS Initial AssSIDS Initial Assessment Report For SIAM 3, CAS no: 102-71-6 (Triethanolamine)
- Author:
- SIDS Initial Assessment Report ,SIAM 3
- Year:
- 1 995
- Bibliographic source:
- SIDS Initial Assessment Report for SIAM 3, Williamsburg, Virginia, 13-16 February 1995
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Repeated insult patch test
- Principles of method if other than guideline:
- The skin sensitization study of Triethanolamine was performed in human by repeated insult patch test.
- GLP compliance:
- not specified
- Type of study:
- other: Repeated insult patch test
- Justification for non-LLNA method:
- Not specified
Test material
- Reference substance name:
- 2, 2’, 2’’-nitrilotriethanol
- Cas Number:
- 102-71-6
- Molecular formula:
- C6H15NO3
- IUPAC Name:
- 2, 2’, 2’’-nitrilotriethanol
- Test material form:
- not specified
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Triethanolamine
- Molecular formula : C6H15NO3
- Molecular weight :149.189g/mole
- Substance type: organic
In vivo test system
Test animals
- Species:
- other: Human
- Strain:
- not specified
- Remarks:
- Not applicable
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, semiocclusive
- Vehicle:
- not specified
- Concentration / amount:
- 0.1% Triethanolamine
- Day(s)/duration:
- 24hr
Challenge
- No.:
- #1
- Route:
- epicutaneous, semiocclusive
- Vehicle:
- not specified
- Concentration / amount:
- 0.1% Triethanolamine
- Day(s)/duration:
- 96 hour
- No. of animals per dose:
- 64 humans
- Details on study design:
- MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures:3 times
- Exposure period:24 hr per application
- Test groups:64
- Control group: No data available
- Site: upper arm
- Frequency of applications: 3 times/ week for 3 week
- Duration:24hr
- Concentrations: 0.1% Triethanolamine
B. CHALLENGE EXPOSURE
- No. of exposures: one
- Day(s) of challenge: After 14 days of last induction patch test
- Exposure period: No data available
- Test groups:64
- Control group: No data available
- Site: opposite arm
- Concentrations: 0.1%
- Evaluation (hr after challenge):48hr and 96hr - Challenge controls:
- No data available
- Positive control substance(s):
- no
Study design: in vivo (LLNA)
- Statistics:
- No data available
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- other: challenge
- Hours after challenge:
- 96
- Group:
- test chemical
- Dose level:
- 1% Triethanolamine
- No. with + reactions:
- 0
- Total no. in group:
- 64
- Clinical observations:
- some signs of mild irritation, but overall no evidence of sensitisation was observed.
- Remarks on result:
- no indication of skin sensitisation
In vivo (LLNA)
- Cellular proliferation data / Observations:
- CLINICAL OBSERVATIONS:some signs of mild irritation, but overall no evidence of sensitisation was observed.
Any other information on results incl. tables
No sensitization observed.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not sensitizing
- Conclusions:
- The skin sensitization study of Triethanolamine was performed by repeated insult patch test in human . The test substance was considered to be not sensitizing.
- Executive summary:
The skin sensitization study of Triethanolamine (102 -17 -6) was performed by repeated insult patch test in 64 human volunteers. By using 0.1%Triethanolamine.
In induction phase, repeated patch applications was done using 0.1% test substance for 24hr per application at upper arm of the volunteers for 3 times per week for 3 weeks .
After 14 days rest period ,challenge application of 0.1% test substance was applied on opposite arm of the subject. Evaluation was performed after 48hr and 96hr.
Some signs of irritation mild to moderate observed after induction phase in very small number of occasion ,after challenge application some signs mild irritation were also observed but no evidence of sensitivity was noted. Hence it is considered that Triethanolamine(102 -17 -6) was not skin sensitizing in human .
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