Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 202-809-6 | CAS number: 100-00-5
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication/study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Experimentelle Untersuchung der allergenen Wirkung von Ortho- und Para-nitrochlorbenzol.
- Author:
- Rusakov NV, Korotkova GI, Biklubatov VS (1973)
- Year:
- 1 973
- Bibliographic source:
- Gig Sanit 3: 13-16
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 3 drops (10 % sol.) to the clipped area of the skin; 22nd day inj. of Freund-adjuvans and TS into the hind paw (0.5 mg/kg bw), d28 1 drop (10 % sol.) to an untreated clipped area of the skin; reading time not mentioned
- GLP compliance:
- no
- Type of study:
- other: modified Freunds complete adjuvant test
Test material
- Reference substance name:
- 1-chloro-4-nitrobenzene
- EC Number:
- 202-809-6
- EC Name:
- 1-chloro-4-nitrobenzene
- Cas Number:
- 100-00-5
- Molecular formula:
- C6H4ClNO2
- IUPAC Name:
- 1-chloro-4-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): Para-nitrochlorbenzol
- Analytical purity: no data
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: epicutaneous, no more informations
- Vehicle:
- other: acetone
- Concentration / amount:
- 10% in acetone
Challengeopen allclose all
- Route:
- other: epicutaneous, no more informations
- Vehicle:
- other: acetone
- Concentration / amount:
- 10% in acetone
- No. of animals per dose:
- 10
- Details on study design:
- 1st application: Induction 10 % 2nd application: Challenge 10 %
- Positive control substance(s):
- not specified
Study design: in vivo (LLNA)
- Statistics:
- no data
Results and discussion
Any other information on results incl. tables
No more data given
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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