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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 200-922-5 | CAS number: 75-98-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report which meets basic scientific principles: pre-GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Pivalic acid
- EC Number:
- 200-922-5
- EC Name:
- Pivalic acid
- Cas Number:
- 75-98-9
- Molecular formula:
- C5H10O2
- IUPAC Name:
- 2,2-dimethylpropanoic acid
- Details on test material:
- - Name of test material (as cited in study report): MRD-64-1
- Substance type: white crystalline powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 34.6, 120, 417, 1450, 5000, 10000
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 000 mg/kg bw
- 95% CL:
- 830 - 4 820
- Clinical signs:
- other: 1450 mg/kg - slight to marked depression, dyspnea and ataxia at 24 hours, and death within 48 hours postdose. survivors showed depression, severe dyspnea, depressed reflexes, sprawling, incoordination, and abnormal gait. 5000 and 10000 mg/kg - depressio
- Gross pathology:
- 5000 and 10000 mg/kg - congestion of lungs, liver, kidneys, and adreneals; pyloric portion of the stiach grossly hemorrhagic.
Any other information on results incl. tables
Time of Death (post-exposure) | ||||||||
Dose (mg/kg-bw) | 1 h | 4 h | 24 h | 2 days | 3 days | 4 days | 5-14 days | |
34.6 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | |
120 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | |
417 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | |
1450 | 0/5 | 0/5 | 0/5 | 2/5 | 2/5 | 2/5 | 2/5 | |
5000 | 0/5 | 0/5 | 3/5 | 5/5 | ||||
10000 | 2/5 | 2/5 | 5/5 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 for neopentanoic acid is 2000 mg/kg. This finding warrants the classification of neopentanoic acid as not classified as an acute toxon under EU GHS guidelines and does not warrant classification under the EU requirements for dangerous substances and preparations guidelines.
- Executive summary:
In this study, male rats were administed neopentanoic acid at doses of 34.6, 120, 417, 1450, 5000, or 10000 via oral gavage. Based on mortality, the estimate LD50 is 2000 mg/kg. This finding warrants the classification of neopentanoic acid as not classified as an acute toxin under EU GHS guidelines and does not warrant classification under the EU requirements for dangerous substances and preparations guidelines.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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