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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The oral gavage O.E.C.D. 407 Testing Guideline 28-day oral repeat dose conducted according to the GLP regulations is the most approriate repeated-dose study for the establishment of DNEL values.  The NOAEL from this study for systemic effects was 30 mg/kg/day.

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Dose descriptor:
NOAEL
30 mg/kg bw/day

Repeated dose toxicity: dermal - systemic effects

Endpoint conclusion
Dose descriptor:
NOAEL
30 mg/kg bw/day

Additional information

The oral NOAEL was determined from a 28 -day repeat dose study to be 30 mg/kg/day. There was a slight decrease in the liver and kidney weights at the 10 mg/kg/day dose level, but this was thought to be incidental. The dermal NOAEL was determined from a ten day repeat dose study to be 30 mg/kg/day.

Justification for classification or non-classification