Registration Dossier

Administrative data

Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Justification for type of information:
It is well established that saturated perfluorocarbons form a class of chemicals with very similar properties.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984
Report Date:
1984

Materials and methods

Test guideline
Guideline:
OECD Guideline 305 A (Bioaccumulation: Sequential Static Fish Test)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Radiolabelling:
no

Test solutions

Vehicle:
yes
Remarks:
HCO-20 (x10) ad F-142D Megafac (x20)

Test organisms

Test organisms (species):
Cyprinus carpio
Details on test organisms:
Sterilised in static solution of chlorotetracycline hydrochloride (10 mg/l) for 24 hours, acclimatised for 14 days.
Average: body weight 22.4g; length 9.7 cm, lipid content 4.2%.

Study design

Route of exposure:
aqueous
Justification for method:
other: Done to support entry into Japanese market at that time
Test type:
flow-through
Water / sediment media type:
natural water
Total exposure / uptake duration:
ca. 8 wk

Test conditions

Test temperature:
23 to 27°C
Dissolved oxygen:
3.0 to 5.4 mg/l
Nominal and measured concentrations:
Level 1: nominal 1.0 mg/l, measured at 0.807, 0.858, 0.846, 0.839
Level 2: nominal 0.1 mg/l; measured at 0.0790, 0.0832, 0.0867, 0.0889
Reference substance (positive control):
not specified

Results and discussion

Bioaccumulation factoropen allclose all
Key result
Conc. / dose:
> 0.8 - < 0.9 mg/L
Temp.:
>= 23 - <= 27 °C
Type:
BCF
Value:
>= 0.2 - <= 4.7 dimensionless
Basis:
whole body w.w.
Time of plateau:
8 wk
Conc. / dose:
> 0.08 - < 0.09 mg/L
Temp.:
>= 23 - <= 27 °C
Type:
BCF
Value:
>= 7.3 - <= 30 dimensionless
Basis:
whole body w.w.
Time of plateau:
8 wk

Applicant's summary and conclusion

Conclusions:
The material exhibits minimal bioconcentration.
Executive summary:

The material exhibits minimal bioconcentration.