Registration Dossier
Registration Dossier
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EC number: 206-386-9 | CAS number: 335-27-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- Note that this is old data from testing done in 1996.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Perflunafene
- EC Number:
- 206-192-4
- EC Name:
- Perflunafene
- Cas Number:
- 306-94-5
- Molecular formula:
- C10F18
- IUPAC Name:
- 1,1,2,2,3,3,4,4,4a,5,5,6,6,7,7,8,8,8a-Octadecafluoronaphthalene
- Test material form:
- other: liquid
- Details on test material:
- F2 Chemicals Ltd internal identifier: L40092
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Acclaimised at least 5 days, housed in gril-bottomed metal cages, fed antibiotic-free diet and mains water, kept at 17-21°C 44-65% relative humidity
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- Single exposure directly to right eye
- Observation period (in vivo):
- 72 hour
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Modified Kay and Calandra scale
- Basis:
- mean
- Time point:
- other: 1 hr
- Score:
- ca. 0
- Max. score:
- 0
- Irritation parameter:
- other: Modified Kay and Calandra scale
- Basis:
- mean
- Time point:
- other: 24 hr
- Score:
- ca. 0
- Max. score:
- 0
- Irritation parameter:
- other: Modified Kay and Calandra scale
- Basis:
- mean
- Time point:
- other: 48 hr
- Score:
- ca. 0
- Max. score:
- 0
- Irritation parameter:
- other: Modified Kay and Calandra scale
- Basis:
- mean
- Time point:
- other: 72 hr
- Score:
- ca. 0
- Max. score:
- 0
- Irritant / corrosive response data:
- "There were no apparent signs of irritation in the treated eye of any animal throughout the 72 hour observation period.
The maximum mean irritation score was 0.0."
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- "Under the conditions of this study, the test article, FLUTEC PC6, is considered to be non irritating to the eye of the albino rabbit."
- Executive summary:
"Under the conditions of this study, the test article, FLUTEC PC6, is considered to be non irritating to the eye of the albino rabbit."
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