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EC number: 944-288-4 | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects on aquatic algae up to the limit of water solubility, read across.
Key value for chemical safety assessment
Additional information
Data on the acute toxicity of the target substance Fatty acids, C8-12, isopentylesterto aquatic algae are not available. The assessment was therefore based on studies conducted with the structurally similar substances Isopropyl myristrate (CAS 110-27-0) and octyl oleate (CAS 2306-88-9) as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Further justification is given within the overall summary chapter 6.1 and within the analogue justification in IUCLID section 13.
The toxicity of the source substance Isopropyl myristrate (CAS 110-27-0) to Desmodesmus subspicatus was tested according to EU Method C.3 and to GLP (Rieche, 1995). The test was performed as a limit test at a nominal substance concentration of 100 mg/L. Two parallel test approaches were performed. In the first approach the test solution was not filtered before the algal cells were added whereas in the second approach the test solution was filtered before use. No effects on the algal growth rate were observed after 72 hours of exposure (ErC50 (72 h) > 0.05 mg/L, measured) in the filtered emulsion of the test medium. In the unfiltered emulsion, presumably physical effects were observed leading to an ErC50 < 100 mg/L, nominal. In a second study the acute toxicity of the source substance octyl octanoate (CAS 2306-88-9) to algae was tested according to OECD Guideline 201 and GLP (Caduff, 2013). The test organism Desmodesmus subspicatus was exposed to the test substance at a nominal loading of 100 mg/L, prepared as water soluble fractions (WSF), for 72 hours. No significant effect on algal growth was observed. The EL50 (72 h) based on growth rate was determined to be > 100 mg/L and the NOELR (72 h) >= 100 mg/L.
Based on the results of the read across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) toxic effects ofFatty acids, C8-12, isopentylesterto aquatic algae are not expected.
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