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EC number: 944-288-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Fatty acids, C8-12, isopentylester has a low potential to bioaccumulate.
Key value for chemical safety assessment
Additional information
Experimental data investigating the bioaccumulation potential of Fatty acids, C8-12, isopentylesterare not available. The substance components are characterised by a log Pow > 5 indicating a potential to bioaccumulate in biota. However, the information gathered on environmental behaviour and metabolism in combination with the QSAR-estimated BCF values provide enough evidence (in accordance with REACh Regulation (EC) No. 1907/2006, Annex XI General rules for adaptation of the standard testing regime set out in Annexes VII to X, 1.2, to cover the data requirements of Regulation (EC) No. 1907/2006, Annex IX) to state that the substances is not likely to bioaccumulate.
The substance is considered readily biodegradable and is insoluble in water (water solubility: 2 - 50 µg/L at 20 °C). According to the Guidance on information requirements and chemical safety assessment, Chapter R.7b, readily biodegradable substances are expected to undergo rapid and ultimate degradation in most environments, including biological Sewage Treatment Plants (STPs). Furthermore, the guidance document states that once insoluble chemicals enter a standard STP, they will be extensively removed in the primary settling tank and fat trap and thus, only limited amounts will get in contact with activated sludge organisms (ECHA, 2014). Therefore, after passing through conventional STPs, only low concentrations of these substances are likely to be (if at all) released into the environment. If released to the water the substance will tend to bind to sediment and other particulate organic matter due to their hydrophobicity and relatively high adsorption potential. Thus, the most relevant exposure route for aquatic organisms such as fish will be via food ingestion or contact with suspended solids. If the substance is ingested by organisms a fast metabolisation is expected. The substance is expected to be hydrolysed by lipases. The resulting free fatty acids and alcohols are absorbed from the intestine into the blood stream. The alcohols are metabolised primarily in the liver through a series of oxidative steps, finally yielding carbon dioxide (Berg et al. , 2001). Fatty acids are either metabolised via the beta-oxidation pathway in order to generate energy for the cell or reconstituted into glyceride esters and stored in the fat depots in the body (Berg et al., 2001). Lipids and their constituents, fatty acids, are in particularly a major organic constituent of fish and play major roles as sources of metabolic energy (Tocher, 2003). The main route of excretion is via expired air as CO2, and the second route of excretion is by biliary excretion and faeces.
According to the Guidance on information requirements and chemical
safety assessment, Chapter R.7c (ECHA, 2014), even though ready
biodegradability does not per se preclude bioaccumulation potential,
generally (depending on exposure and uptake rates) ready biodegradable
substances are likely to be rapidly metabolised, and therefore,
concentrations stored in aquatic organisms will tend to be low.
Estimated bioconcentration (BCF) and bioaccumulation (BAF) values were
calculated for the substance using the BCFBAF v3.01 program (Estimation
Programs Interface Suite™ for Microsoft® Windows v 4.10., US EPA),
assuming biotransformation (Arnot-Gobas method). The estimated BCF
values ranging from 122.1 – 203.1 L/kg calculated for the main
components. The calculated BAF values for the main substance components
ranged between 138 L/kg and 224.6 L/kg (BCFBAF v3.01, Arnot-Gobas,
including biotransformation, upper trophic).
Thus, taking all available information into account, Fatty acids, C8-12, isopentylester has a low potentialto bioaccumulate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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