Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report Date:
2016

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
1.11
Temp.:
20 °C
Remarks on result:
other: pH was not determined

Applicant's summary and conclusion

Conclusions:
The aim of this study was the determination of the n-octanol/water partition coefficient of the test item by high
performance liquid chromatography (HPLC) method according to EC method A.8 and OECD guideline 117.
The analysis was performed on an analytical column packed with a solid phase containing lang hydrocarbon
chains chemically bound onto silica (Luna 5μ C18(2) 100A; 250 x 3.0 mm). A mixture of 60 % methanol and
40 % ultra-pure grade water was used as mobile phase and the column temperature was 20 °C ± 1 °C.
Mean log Pow of two runs: 1.11