Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 617-849-3 | CAS number: 86404-04-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2013
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Cross-reference
- Reason / purpose for cross-reference:
- assessment report
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Molecular structure-dependent cytotoxic effect of ascorbate derivates
- Author:
- Tsao CS, Young M
- Year:
- 1 995
- Bibliographic source:
- In Vitro Cell.Dev.Biol. 31:87-90, February 1995
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Zasshi
- Year:
- 1 963
- Bibliographic source:
- Journal of Medical Society of Toho University. Vol 10, Pag. 1 1963 (CHemIDplus)
- Reference Type:
- secondary source
- Title:
- National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program
- Author:
- NCI
- Year:
- 1 986
- Bibliographic source:
- Vol. JAN1986 (ChemIDplus)
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Yakuri
- Year:
- 1 976
- Bibliographic source:
- Pharmacometrics. Vol 12, p.131 (ChemIDplus)
- Reference Type:
- publication
- Title:
- SIDS Data Set on L-Ascorbic Acid (Vitamin C)
- Author:
- UNEP publications
- Year:
- 1 990
- Bibliographic source:
- www.inchem.org/documents/sids/sids/50817.htmlb
- Reference Type:
- publication
- Title:
- SIDS Data Set on Ethanol
- Author:
- UNEP Publications
- Year:
- 2 004
- Bibliographic source:
- www.inchem.org/documents/sids/sids/64175.pdf
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- FAO
- Year:
- 1 974
- Bibliographic source:
- FAO Nutrition Meetings Report Series. Vol 53A, p. 146, 1974 (ChemIDplus)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: different guidelines followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ascorbyl palmitate
- IUPAC Name:
- Ascorbyl palmitate
- Reference substance name:
- Ascorbic acid derivatives
- IUPAC Name:
- Ascorbic acid derivatives
- Reference substance name:
- Ascorbic acid
- EC Number:
- 200-066-2
- EC Name:
- Ascorbic acid
- Cas Number:
- 50-81-7
- IUPAC Name:
- 5-(1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one (non-preferred name)
- Reference substance name:
- Ethanol
- EC Number:
- 200-578-6
- EC Name:
- Ethanol
- Cas Number:
- 64-17-5
- IUPAC Name:
- ethanol
- Details on test material:
- different test materials tested
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- >= 13 - <= 10 000 other: microG
- Based on:
- not specified
- Remarks on result:
- other: results based on many compounds
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 25 070 mg/kg bw
- Based on:
- not specified
- Remarks on result:
- other: mouse, Zasshi (1963)
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 367 mL/kg bw
- Based on:
- not specified
- Remarks on result:
- other: mouse, NCI (1986)
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 11 900 mg/kg bw
- Based on:
- not specified
- Remarks on result:
- other: rat, Yakuri (1976)
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 25 000 mg/kg bw
- Based on:
- not specified
- Remarks on result:
- other: mouse, FAO (1974)
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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