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EC number: 943-552-6 | CAS number: 91844-92-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test performed smiliar to OECD 404 (Draize test), not according to GLP guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Draize skin test: 24 hours instead of 4 hours exposure, observations at 0 and 72 hours (not at 24 and 48 hours), partly abraded skin, 6 animals used
- GLP compliance:
- no
- Remarks:
- Pre-GLP
Test material
- Reference substance name:
- Lemongrass oil
- IUPAC Name:
- Lemongrass oil
- Details on test material:
- - Name of test material (as cited in study report): Lemongrass
- Substance type: Fragrance material
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 - 3.4 kg
- Housing: animals were individually housed
- Diet (e.g. ad libitum): ad libitum, commercial diets
- Water (e.g. ad libitum): ad libitum
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped (one flank) and abraded (alternate flank)
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration: No data
VEHICLE
No data available - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: Back of the rabbit (abraded and non-abraded)
- % coverage: No data
- Type of wrap if used: Two single layers of gauze (approx. 1 square inch) with adhesive tape and wrapped in nonabsorbent binder.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No data
- Time after start of exposure: Immediately
SCORING SYSTEM: in accordance with the Draize method. Effects were scored immediately after removal of the patch and again after 72 hours.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- other: subtotal
- Time point:
- other: 24 and 72h after application
- Score:
- 9.5
- Reversibility:
- no data
- Remarks on result:
- other: Scoring system according to Draize (no details available)
- Irritation parameter:
- edema score
- Basis:
- other: subtotal
- Time point:
- other: 24 and 72h after application
- Score:
- 3
- Reversibility:
- no data
- Remarks on result:
- other: Scoring system according to Draize (no details available)
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 and 72h after application
- Score:
- 3.1
- Max. score:
- 4
- Reversibility:
- no data
- Irritant / corrosive response data:
- No data available.
- Other effects:
- No data available.
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- Under the conditions of this test, a subtotal erythema score of 9.5 and a subtotal edema score of 3.0 was determined for Lemongrass oil. The primary dermal irritation index was established to be 3.1 (maximum of 4). As insufficient details are available on the scoring of the skin reactions, no conclusion with respect to EU classification could be drawn. The substance was considered to be moderately irritating.
- Executive summary:
In this study the potential of Lemongrass oil with respect to skin irritation was assessed in a Draize test performed in six rabbits (similar to OECD guideline 404). The test substance was applied to both flanks, one with skin abraded and one with intact skin, of each rabbit. The treated areas were immediately covered with gauze which stayed on for 24 hours. 24 and 72 hours after test substance application the treated skin sites were scored for erythema and oedema by using the Draize scoring system. No details were available on the scoring of the skin reactions.
Under the conditions of this test, a subtotal erythema score of 9.5 and a subtotal edema score of 3.0 was determined for Lemongrass oil. The primary dermal irritation index was established to be 3.1 (maximum of 4). As insufficient details are available on the scoring of the skin reactions, no conclusion with respect to EU classification could be drawn. The substance was considered to be moderately irritating.
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