Methyl methanesulphonate

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from peer reviewed journal

Data source

Reference

Reference Type:

publication

Title:

Occupational Contact Dermatitis to Mesylisopropyllactate

Author:

van Joost T, Schulten-Lukassen M, Stolz E, Smit AF, Ribbens PH

Year:

1984

Bibliographic source:

Contact Dermatitis, Vol. 10, No. 3, pages 187-188, 1984

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

A patch test was conducted on a 40 years old man who worked for 2 years in a chemical factory for the chemical Methanesulphonyl chloride (CAS no: 124-63-0) in accordance with ICDRG batteries.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Methanesulphonyl chloride

EC Number:

204-706-1

EC Name:

Methanesulphonyl chloride

Cas Number:

124-63-0

Molecular formula:

CH3ClO2S

IUPAC Name:

Methanesulphonyl chloride

Test material form:

liquid

Specific details on test material used for the study:

- Name of test material (as cited in study report): Mesyl chloride (MSC)
- Molecular formula: CH3ClO2S
- Molecular weight: 110.1324 g/mol
- Substance type: Organic
- Physical state: liquid
- InChI: 1S/C2H6O3S/c1-5-6(2,3)4/h1-2H3
- Smiles: COS(=O)(=O)C

Test animals

Species:

other: Human

Strain:

other: Not applicable

Details on test animals or test system and environmental conditions:

The patient developed an eczematous eruption on both hands and on left upper leg in September 1982. After his work was discontinued and the skin lesions were treated (hydrocortisone acetate 1% cream) the eczema disappeared within 3 weeks. On resuming his work as a process operator, a similar eruption reappeared on the arm (not on the hands), face and his after a short period.

Test system

Type of coverage:

occlusive

Preparation of test site:

not specified

Vehicle:

other: Petrolatum

Controls:

yes

Amount / concentration applied:

0.2%

Duration of treatment / exposure:

72 hours

Observation period:

48 and 72 hours

Number of animals:

1 (40 year old man): test group
10 person: control group

Details on study design:

No data available

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

72 h

Score:

1

Max. score:

1

Reversibility:

not specified

Remarks on result:

positive indication of irritation

Irritant / corrosive response data:

Positive (++) skin reactions were observed.

Applicant's summary and conclusion

Interpretation of results:

Category 2 (irritant) based on GHS criteria

Conclusions:

The chemical Methanesulphonyl chloride (CAS no: 124-63-0) was considered as irritating to the skin in a patch test conducted on a 40 years old man.

Executive summary:

A patch test was conducted on a 40 years old man who worked for 2 years in a chemical factory for the chemical Methanesulphonyl chloride (CAS no: 124-63-0) in accordance with ICDRG batteries.

 

During the patch test, a patient was tested at a dose of 1% in petrolatum which resulted into strong positive (+++) reaction after 48 and 72 hours. After 6 weeks the patient was retested at lower concentrations of0.5%, 0.2%,0.1% and 0.005% in petrolatum and skin was examined after 48 and 72 hours.

 

Out of 10 control persons, no positive reactions were observed at 0.2% and a negative reaction was observed at 0.1% in test patient.

 

From the tested concentrations, a strong positive(++)reaction was observed at 0.2%. Thus the chemical Methanesulphonyl chloride (CAS no: 124-63-0)considered as irritating to the skinin a patch test conducted ona 40 years old man.