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EC number: 231-850-2
CAS number: 7759-02-6
Brief exposure of recently ovulated mouse
oocytes in M16 embryo culture medium supplemented with 1.6 mM SrCl2
for 2-10 min resulted in induction of a high incidence of
parthenogenones. A lower incidence of activation and a significant rate
of oocyte degeneration were observed when oocytes were incubated in M16
Sr2+ medium for 20-60 min. The majority of oocytes exposed to
M16 Sr2+ for 2-10 min developed as single-pronuclear haploid
parthenogenones (1PN). The incidence of this parthenogenetic class was
reduced as the exposure time to M16 Sr2+ was increased from 2
to 30 min. Under these conditions a greater proportion of the activated
oocytes developed as two-pronuclear diploid parthenogenones, due to the
failure of second polar body extrusion. The activation frequency and the
proportionate incidence of the pathways of parthenogenetic development
following the exposure of ovulated oocytes to Ca-free M16 medium
differed significantly from that induced by M16 Sr2+.
Cytogenetic analysis of the single-pronuclear haploid class of Sr2+
induced parthenogenones at metaphase of the first-cleavage mitosis
showed that this agent did not induce an increased incidence of
chromosome segregation errors during the completion of the second
meiotic division. Analysis of the developmental potential of the
two-pronuclear class of diploid Sr2+ induced parthenogenones
during the pre-implantation stages of embryogenesis revealed that their
cell number and rate of cell division were less than those of fertilised
embryos retained either in vivo or in vitro.
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