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Diss Factsheets
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EC number: 618-777-5 | CAS number: 91662-51-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: study performed according to OECD and GLP guidelines, test result not conclusive
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Zeanyne salt
- EC Number:
- 618-777-5
- Cas Number:
- 91662-51-0
- Molecular formula:
- C33H36ClOP
- IUPAC Name:
- Zeanyne salt
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Doses:
- 500 and 2000 mg/kg
- No. of animals per sex per dose:
- 5 per sex per dose
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: LD50 not determined
- Effect level:
- <= 500 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
Single dose administration of 2000 mg/kg or 500 mg/kg induced laborious or stertorous
breathing or increased salivation. Several animals died or were sacrificed in a
moribund condition within a few days after dosing. In general, the cause of poor
condition or death of the rats remained unclear. The findings in the gastrointestinal
tract are indicative of functional disturbances. The marked difficulties in breathing might
be due to the distention of the stomach, although it was not noted in all affected
animals. The pathogenesis of the tubulonephrosis observed in one female is unclear. It
might be related to the extreme body weight loss probably with resulting dehydration
observed in this animal.
Applicant's summary and conclusion
- Interpretation of results:
- other: substance is considered to be harmful or toxic
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- According to OECD or EU guidelines for chemicals, Zeanyne salt is considered to
be harmful if swallowed. The LD50 is estimated to be <2000 mg/kg > 500mg/kg - Executive summary:
The acute oral toxicity of Zeanyne salt was investigated in Wistar rats (5 rats/sex/group).
Single dose administration of 500 mg/kg or 2000 mg/kg of Zeanyne salt induced laborious or stertorous breathing or increased salivation. At 2000 mg/kg, 7/10 rats and at 500 mg/kg, 2/10 rats died or were sacrificed in a moribund condition
within a few days after dosing. At necropsy, a distention of the gastrointestinal tract and/or an abnormal intestinal content were found in some of the rats which died or were sacrificed prematurely. These findings are indicative of functional disturbances.
Microscopic findings in the lungs and kidneys observed in individual animals are considered not to be directly related to treatment.
Single dose administration of 500 mg/kg in the rat induced severe adverse effects and deaths. In general, the cause of poor
condition or death of the rats is unclear.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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