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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Not applicable
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: 2e: Meets generally accepted scientific standards, well-documented and acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
No information
Author:
Smyth, H.F. et al
Year:
1962
Bibliographic source:
Am Ind Hyg Assoc J, vol 23 ; p. 95
Reference Type:
publication
Title:
Unnamed
Year:
1956

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Groups of 5 male rats were dosed with the test material at various doses and observed for 14 days
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-piperazin-1-ylethylamine
EC Number:
205-411-0
EC Name:
2-piperazin-1-ylethylamine
Cas Number:
140-31-8
Molecular formula:
C6H15N3
IUPAC Name:
2-piperazin-1-ylethanamine
Details on test material:
AEP reported to contain 2.5% diethylenetriamine.

Test animals

Species:
rat
Strain:
other: Carworth-Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
Animals were reared in the laboratory the study was conducted at and maintained on Rockland rat diet.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
Test material was administered by oral gavage.
Doses:
Rats were dosed with 1.0, 2.0, 3.98 or 7.95 ml/kg AEP.
No. of animals per sex per dose:
5 males
Control animals:
not specified
Details on study design:
Carworth-Wister non-fasted rats, 5-6 weeks of age and 90-120 grams in weight were dosed at levels differing by a factor of 2.0 in a geometric series.
Statistics:
Thompson's method of calculating the median-effective dose (LD50) was applied to the 14-day mortality data.

Results and discussion

Preliminary study:
Not applicable
Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 2 097 mg/kg bw
Mortality:
Two of five rats died at 2.0 ml/kg and all rats died at 3.98 and 7.95 ml/kg. All animals died within 24 hours.
Clinical signs:
other: No additional information available.
Gross pathology:
At necropsy, lungs were found to be slightly congested, livers mottled, kidneys congested internally but pale externally, and stomach, intestine and adrenal hemorrhaged.
Other findings:
No additional information available.

Any other information on results incl. tables

The oral LD50 was calculated to be 2.14 ml/kg. Given a density of 0.98 g/cc, the oral LD50 is considered to be 2097 mg/kg.

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Remarks:
Migrated information
Conclusions:
The acute oral LD50 was 2097 mg/kg.
Executive summary:

The acute oral toxicity of aminoethylpiperazine was determined. The acute oral LD50 was 2097 mg/kg.