Registration Dossier
Registration Dossier
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EC number: 701-006-2 | CAS number: 30008-10-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
Skin sensitisation
The sensitisation potential of the target substance sodium 4-hydroxyphenolate (EC 701-006-2) was determined by read-across from the harmonized classification for hydroquinone (EC 204-617-8). The target molecule, Sodium 4-hydroxyphenolate has the same molecular structure as the free phenol hydroquinone, with the exception that one proton on one of the phenolic group is replaced by sodium. In aqueous solution, both substances have a pH-dependent equilibrium, which is governed by the pKa value of the phenolic hydrogens (ca. 9.95 in water). The target substance is an ionic species that contains in its registered form ca. 30 % water. Vehicles used in skin sensitization assays typically are non-aqueous or contain lipophilic components. The effect of vehicle on skin sensitization effects of hydroquinone have been reported, with more marked effects observed with for example, acetone/physiological saline (1:1) than with for example, acetone or methyl ethylketone. The target substance, being 30 % water by weight, may be expected to be present in equilibrium with the hydroquinone in the selected vehicle, and hence hydroquinone is considered a suitable source substance from which to read across this endpoint. As a conclusion, the skin sensitisation potential of sodium 4-hydroxyphenolate is estimated to be similar to that of hydroquinone.
Migrated from Short description of key information:
The sensitisation potential of the target substance sodium 4-hydroxyphenolate (EC 701-006-2) was determined by read-across from the harmonized classification for hydroquinone (EC 204-617-8).
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Skin sensitisation
Sodium 4 -hydroxyphenolate (EC 701 -006 -2) is classified as a skin sensitiser Category 1 based on read-across from the harmonized classification for hydroquinone (EC 204 -617 -8).
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