Registration Dossier
Registration Dossier
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EC number: 701-006-2 | CAS number: 30008-10-7
Endpoint summary
Administrative data
Description of key information
The acute oral toxicity of the target substance sodium 4-hydroxyphenolate (EC 701-006-2) was determined by read-across from the harmonized classification for hydroquinone (EC 204-617-8).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute Oral Toxicity
The acute oral toxicity of the target substance sodium 4-hydroxyphenolate (EC 701-006-2) was determined by read-across from the harmonized classification for hydroquinone (EC 204-617-8). The target molecule, Sodium 4-hydroxyphenolate has the same molecular structure as the free phenol hydroquinone, with the exception that one proton on one of the phenolic group is replaced by sodium. In aqueous solution, both substances have a pH-dependent equilibrium, which is governed by the pKa value of the phenolic hydrogens (ca. 9.95 in water). Upon oral administration, the sodium 4-hydroxyphenolate first mixes with the acidic medium in the stomach. The pH of gastric fluid varies widely with the species and the nutritional status. Values for humans are of 1.7 (1.4 - 2.1) in the fasted state, and 5.0 (4.3 - 5.4) upon food intake. For rats, pH in the median anterior portion of the stomach is reported to be 5.0, in the median posterior portion 3.0, without reference to feeding state. Despite the variations, it is concluded that in gavage applications the test substance is always exposed to a pH around or below 2, which converts the sodium salt to the free phenol, since this route is normally applied to fasted animals. From this point on, the source chemical and target chemical will be indistinguishable. As a conclusion, the acute oral toxicity of sodium 4-hydroxyphenolate is estimated to be similar to that of hydroquinone.
Justification for classification or non-classification
Acute oral toxicity
Sodium 4-hydroxyphenolate (EC 701-006-2) is classified as acutely toxic by oral route category 4 based on a read-across from the harmonized classification for hydroquinone (EC 204-617-8).
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