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EC number: 231-820-9 | CAS number: 7757-82-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Test results available for acute toxicity rat (oral and inhalation).
LC50, 4h (rat, inhalation) > 2400 mg/m3 air
LCLo, 72h (rat, inhalation) > 10 mg/m3 air
Based on the results of several acute toxicity inhalation studies it is unlikely that short-term inhalation of respirable sodium sulfate particles cause pulmonary irritation or systemic effects;
The acute dermal toxicity (rat) is waived: Annex XI adaptation- inorganic ionic substance low potential for absorption through the skin.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Value:
- mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 2 400 mg/m³ air
Additional information
ORAL
LD50 (rat, oral) > 2000 mg/kg (test substance)
LD50 (rat, oral) > 10 g/kg (Henkel)
DERMAL
No data. Waived. Given the complete dissociation in solution, penetration through the intact skin is not to be expected.
INHALATION
LC 50, 4h (rat, inhalation) > 2.4 mg/L air (gravimetrically determined mean aerosol concentration)
LCLo, 72h (rat, inhalation) > 10 mg/m3 air
In an acute inhalation study performed at Harlan Labs (Pothmann D., 2010) the ranges of aerosol concentration, temperature, relative humidity, oxygen content and airflow rate measured during the exposure were considered to be satisfactory for a study of this type. In addition, the test item was considered to be respirable to rats. All animals survived the scheduled observation period.
Ruffled fur was recorded in all animals one hour after the end of exposure and on test day 2. From test day 3 onwards no clinical signs were observed. Slight effects on body weight were recorded during the observation period. There were no macroscopic findings during necropsy.
It was concluded that the LC50 of Sodium Sulphate obtained in this study was estimated to be greater than 2.4 mg/L air (gravimetrically determined mean aerosol concentration) which was the highest technically feasible aerosol concentration.There was no indication of relevant sex-related differences in toxicity of the test item.
In an inhalation toxicity study (according to Last and Cross, J. Lab. Clin. Med. 91: 328-339 (1978)), 6 male Sprague-Dawley rats were exposure to aerosols of sodium sulfate at levels of 10 mg/m3 for 72 hours. The responses to breathing these aerosols were evaluated by measurements of glycoprotein, RNA and DNA contents of homogenates of the lungs and quantification of wet to dry weight ratios of the lung lobs. No mortality was reported. The RNA, DNA and protein levels were 99, 100 and 107, respectively (the control values were 100). The lung wet to dry ratio was 4.35 in the first experiment and 4.5 in the second experiment (control value was 4.5) (Last, 1980).
In another experiment the bronchial mucociliary clearance was measured in 5 male rabbits by brief inhalation of radiolabelled, insoluble tracer microspheres (99mTc-tagged ferric oxide). The thoracic retention was measured externally in vivo. These measurements began within 2 min. after the inhalation and were repeated after 24 hours to determine a value for residual activity. The mucociliary clearance was determined as mean residence time (MRT) of the tracer. No effect on mucociliary clearance was found (one way ANOVA, two tailed) (Schlessinger, 1984).
The intestinal effects of sulfate in drinking water (up to 1200 mg/l) on normal human subjects (10) has been investigated. The health of the subjects was determined by studying their history, physical examination, urine analysis, blood cell counts and serum chemistry. During the study stool mass, frequency and consistency in mouth to anus appearance of colored markers were measured. No significant change in bodyweight was observed. All blood and urine test results were normal. At 1200 mg/l 8 subjects rated the taste of the water as neutral-slightly unpleasant, 1 subject as moderately unpleasant and 1 subject as very unpleasant. Significant decreases in stool consistency and appearance time were noted at 1200 mg/l, compared to the control (Heizer, 1997).
Justification for classification or non-classification
Based on the test results and supporting data (rat: oral and inhalation) and on the waiver (dermal) the substance Sodium sulphate should not be classified.
Based on the absence of major significant effects, sodium sulfate does not need to be classified for acute toxicity according to EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP).
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