Registration Dossier
Registration Dossier
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EC number: 204-506-4 | CAS number: 121-91-5
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No studies are available on the long-term toxicity of the free acid form of isophthalic acid to freshwater invertebrates, however a reliable (Klimisch 1, guideline- and GLP- compliant) study addresses the long-term toxicity of its structural analogue terephthalic acid.
In this study (Government of Japan, Ministry of the Environment, 2003c), Daphnia magna were exposed to high purity TPA (free acid), dosed from a stock solution prepared with DMSO, at a concentration intended to approximate to TPA's aqueous solubility limit. No toxicity was observed under these test conditions:
D. magna 21 -d NOEC (semi-static): 19.5 mg TPA/L.
This endpoint is a mean measured value and represents the maximum limit concentration achievable under the test conditions. It demonstrates anabsence of toxicity at concentrations up to the solubility limit of TPA in water. Based on read-across, isophthalic acid is expected to exhibit low long-term toxicity to aquatic invertebrates.
Key value for chemical safety assessment
Additional information
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