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Diss Factsheets
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EC number: 204-506-4 | CAS number: 121-91-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
The atmospheric oxidation half-life of isophthalic acid was estimated using the AOPWIN v1.91QSAR model available from the US EPA. The estimated atmospheric oxidation DT50 of isophthalic acid ranged from 8.18 days (default settings) to 12.27 days, estimated by applying the recommended northern hemisphere settings that are considered relevant in a European context.
Since isophthalic acid is readily biodegradable, a formal study of the hydrolysis behaviour of IPA at three pH values is not required and has not been performed. Nevertheless, some insight is provided by a study of the toxicity of IPA (converted to its sodium salt(s) prior to test initiation) to unicellular aquatic algae (Knacker et al., 1993c). The IPA-equivalent concentrations, initially dosed to non-sterile aqueous algal growth test medium at 67.9, 298 and 1023 mg/L (measured), were reduced by - on average - ca. 16% over the course of 96-h incubation at pH ca 7and 23 degrees C. Although this small reduction may have been the result of biodegradation, photolysis, hydrolysis or any combination of these processes, these data (DT50 > 4 days) provide clear evidence that IPA is not prone to rapid hydrolysis in the aquatic environment.
Similarly, no studies are required or have been performed to investigate the phototransformation of isophthalic acid in water, however the results of the same algal study, in which IPA remained stable following continuous bright illumination for 96 hours, suggests that isophthalic acid is not prone to rapid photodegradation.
In summary isophthalic acid is generally resistant to physico-chemical degradation processes under the range of conditions likely to be encountered in the aquatic and terrestrial environment. Other data (see Point 5.2.1) show that isophthalic acid is readily biodegradable, with >60% mineralisation (oxidation to CO2) occurring within 5 to 7 days. Biodegradation may therefore be considered a more significant dissipation mechanism than physico-chemical processes tor IPA in the environment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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