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EC number: 205-582-1
CAS number: 143-07-7
NOELR (21d) >= 1.3 mg/L (measured, TWA), RA from decanoic acid (CAS 334-48-5)
A study on the long-term toxicity of lauric acid (CAS 143 -07 -7) to
aquatic invertebrates is available. This GLP study (Ministry of the
Environment of Japan, 2001) was conducted according to OECD 211 and
showed a NOEC (21 d) of 0.47 mg/L for Daphnia magna. Since severe
deficiencies such as an invalid solvent control, instable test substance
concentration, no defined dose-response curve and unknown fate of the
test substance had been stated, the study was considered to be
Therefore currently no reliable Daphnia Magna Reproduction study
according to OECD 211 is available for lauric acid.
In the context of an ongoing test programme in cooperation with
Fraunhofer Institute IME (FhG) in Schmallenberg/Germany in 2012 a new
OECD 211 study with decanoic acid (CAS 334 -48 -5) was performed. The
study was set up as limit test, in which the test item was prepared as
WAF with a nominal loading of 5 mg/L and the medium was replaced daily.
Samples were taken for chemical analysis from fresh and aged media
during three representative 24 hours exposure periods per week. No
immobilisation of daphnia occured throughout the test, neither the mean
cummulative offspring was affected. Based on the measured time weighted
average concentration (TWA), a NOELR >= 1.3 mg/L has been determined
(corresponding to the nominal load of 5 mg/L).
This result is currently used as read across to chronic daphnia toxicity
of C12 fatty acid (lauric acid). A detailed justification for the
grouping of chemicals and read-across is provided in the Chemical Safety
Report (CSR, see section 13 of the technical dossier).
A chronic toxicity study with lauric acid is in progress in order to
overcome methodological deficiencies due to rapid decay of the test
substance and to verify the hazard assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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