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EC number: 205-582-1
CAS number: 143-07-7
Studies on the acute aquatic toxicity of lauric acid (CAS
143-07-7) are available for all three trophic levels (fish,
invertebrates and algae), resulting in LC50(96h) of 5.0 mg/L for fish
and and EC50(48h) of 3.6 mg/L for daphnia, respectively. The toxicity
study on algae showed no effects up to the limit of water solubility.
Chronic fish toxicity data with lauric acid are not available.
Therefore chronic fish toxicity data from a surrogate substance, sodium
laurate (CAS 629-25-4, C12) are taken into account. From this test it
can be concluded, that long-term effects on fish up to the limit of
water solubility are also not to be expected for lauric acid.
One long term toxicity study on invertebrates with lauric acid is
available (NITE 2001). Since severe deficiencies such as an invalid
solvent control, instable test substance concentration, no defined
dose-response curve and unknown fate of the test substance had been
stated, the study was therefore disregarded. The chronic toxicity on
daphnia was assessed based on a study for decanoic acid (CAS 334-48-5)
that was conducted recently within an ongoing test programme in
cooperation with Fraunhofer Institute IME (FhG) in Schmallenberg/Germany
in 2012. In the test no immobilisation occurred throughout the test,
neither the mean cumulative offspring was affected by the test
substance. NOELR of >= 1.3 mg/L (measured, TWA) was determined that is
corresponding to the nominal loading of 5 mg/L. An additional study on
chronic invertebrate toxicity with lauric acid is underway in order to
overcome methodological deficiencies due to rapid decay of the test
substance and to verify the hazard assessment.
toxicity to microorganisms is covered by read across data from octanoic
124-07-2) which showed no toxic effect (EC10 (18 h) = 912 mg/L). In the
light of this study no toxic effects on microorganisms (Pseudomonas
putida) can be deduced for lauric acid.
A detailed justification for the grouping of chemicals and
read-across is provided in the Chemical Safety Report (CSR, see section
13 of the technical dossier).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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