Registration Dossier
Registration Dossier
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EC number: 293-671-6 | CAS number: 91081-64-0 Slag produced during ilmenite smelting (ore or sand). Consists primarly of TiO2, FeO, Al2O3, SiO2, MgO and other metal oxides.
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Reliable data for bioaccumulation of Ti in fish are available, based on a bioaccumulation experiment with TiO2 in rainbow trout (read-across with TiO2). Federici et al. (2007) performed accumulation experiments with rainbow trout (Oncorynchus mykiss) in tap water using powder form of TiO2 nanoparticles. After 7 to 14 days of exposure the authors noticed very similar concentrations of Ti in different fish tissues (gills, liver, muscle, brain), i.e. between 11,5 and 21,1 mg Ti/kg dw, irrespective of the added Ti concentrations in the aqueous test medium. Poor adsorption into internal organs and therefore no bioaccumulation of Ti was concluded resulting in BCF values between 19 and 352 L/kg dw..
Key value for chemical safety assessment
Additional information
Reliable data for bioaccumulation of Ti in fish are available, based on a bioaccumulation experiment with TiO2 in rainbow trout. These results can be used in a read-across approach for UGI, since it is assumed that at equilibrium UGI-derived Ti will have the same fate and distribution as the ambient Ti in the environment. BCF’s of Ti are very low and therefore a significant transfer in the food chain is not expected. Indeed, data on the bioaccumulation of Ti clearly show that a significant bioaccumulation in fish is not likely to occur.
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