Registration Dossier
Registration Dossier
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EC number: 248-145-0 | CAS number: 26966-75-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Pre guideline, pre GLP study. Few data reported, observation duration not given
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: list VIII
- Author:
- Carpenter CP, Weil CS & Smyth HF
- Year:
- 1 974
- Bibliographic source:
- Toxicol.Appl.Pharmacol. 28: 313-9
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPP 81-2 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- single sex tested, observation period not specified.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3(or 4)-methylbenzene-1,2-diamine
- EC Number:
- 248-145-0
- EC Name:
- 3(or 4)-methylbenzene-1,2-diamine
- Cas Number:
- 26966-75-6
- Molecular formula:
- C7H10N2
- IUPAC Name:
- 3(or 4)-methylbenzene-1,2-diamine
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- Conditions - standard for the laboratory: under VINYLITE covering
- Duration of exposure:
- no data
- Doses:
- 2000, 1000, 500, mg/kg bw
- No. of animals per sex per dose:
- 4 animals per group sex unspecified
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 120 mg/kg bw
- 95% CL:
- 618 - 2 040
- Gross pathology:
- Congestion throughout lungs, and abdominal viscera. Liver pale and mottled with acini prominant:kidney often pale and mottled
Any other information on results incl. tables
| dose mg/kg bw | Dead / dosed days to death | weight change skin irritation | signs / symptoms | ||
| 2000 | 4 / 4 | 1, 1, 1, 1, | - | - - | |
| 1000 | 1 / 4 | 1 | +, -, -, -, | ||
| 500 | 1 / 4 | 5 | +, +, -, -, |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
