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EC number: 248-145-0 | CAS number: 26966-75-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
Description of key information
In the Cowen et al (1996) study Koc values were determined for 2,4-TDA. Under aerobic conditions Koc values were 1339 and 9768 after 8h and 7d respectively. Under anaerobic conditions the determined values were 884 and 4454 after 8h and 7d respectively. Significantly the experiments with
radiolabelled 2,4- and 2,6 -TDA revealed that the substances form covalent bonds with the organic fraction in soils and therefore the term Koc is not quite correct. Similar behaviour is expected with ortho-TDA
Key value for chemical safety assessment
Additional information
Initial sorption of both isomers in silt loam soil was rapid under both aerobic and anaerobic conditions. Further, sorption appeared to be slowed and still proceeding after 7 days.
2,4-TDA. Under aerobic conditions, Koc values were determined to be 1339 l.kg-1 after 8 hours and 9763 l.kg-1 after 7 days. Under anaerobic conditions Koc values were found to be 884 l.kg-1 and 4454 l.kg-1 after 8 hours and 7 days respectively.
Furthermore, surface adsorption or ion exchange processes were found with minerals without organic content. It should be kept in mind that the term "KOC" generally describes the distribution of a substance between the pore water and the organic matter when the substance is physically bound; if chemisorption occurs the use of this term is not quite correct. TDA has been shown to irreversibly (i.e. covalently) bind with soils under normal aerobic condition. This binding is suppressed under low redox conditions (i.e. anaerobic). This behaviour is consistent with the literature where aromatic amino groups are known to chemically react with aldehyde and keto groups as well as double bonds of quinoid systems typically found in humic substances present in soils. Under low redox conditions such groups / quinoid systems would not be available for reaction with the amino moiety.
2,4-TDA (CAS number 95-80-7) is a structural analogue of ortho-TDA isomers and is used to address the endpoints for biodegradation, toxicokinetics and sensitisation. 2,4-TDA is a structural isomer of o-TDA, differing in the substitution pattern of the amine groups on the tolyl ring; having similar physical chemical properties; similar environmental fate; and similar health effects (acute toxicity and genotoxicity). As a result, data from 2,4 -TDA can be used for read across to 2,3- TDA.
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