Registration Dossier

Administrative data

Endpoint:
toxicity to reproduction: other studies
Type of information:
experimental study
Study period:
2006, 2011
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: guideline evaluation, medical standard procedure

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
2011
Reference Type:
publication
Title:
Unnamed
Year:
2010
Reference Type:
publication
Title:
Acute toxic effects of dioctyltin on immune system of rats
Author:
Kishi et al.
Year:
2006
Bibliographic source:
Environmental and Pharmacology 22 (2006) 240-247
Reference Type:
publication
Title:
Unnamed
Year:
1988

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
other: OECD 431
Deviations:
not applicable
Principles of method if other than guideline:
see free text
GLP compliance:
not specified
Type of method:
in vivo

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: see free text
Details on test material:
-

Test animals

Species:
rat
Strain:
other: see free text
Sex:
male/female

Administration / exposure

Route of administration:
other: see free text
Type of inhalation exposure (if applicable):
not specified
Vehicle:
other: see free text
Analytical verification of doses or concentrations:
yes
Duration of treatment / exposure:
see free text
Frequency of treatment:
see free text
Duration of test:
see free text
No. of animals per sex per dose:
see free text
Control animals:
other: see free text

Results and discussion

Effect levels

Dose descriptor:
other: see free text
Sex:
male/female
Basis for effect level:
other: see free text
Remarks on result:
not measured/tested
Remarks:
Effect level not specified (migrated information)

Applicant's summary and conclusion

Conclusions:
Tonk and Menke dedermined no adverse effect for reproduction and develomental in rat caused by Dioctyltin dichloride. The adverse effect in immune system is considered an acute effect, this is shown by Kishi. The adverse effect is completly reversible withhin a recovery time.