Registration Dossier
Registration Dossier
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EC number: 202-180-8 | CAS number: 92-70-6
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Guideline study but only study abstract available
Data source
Reference
- Reference Type:
- grey literature
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Qualifier:
- according to guideline
- Guideline:
- JAPAN: Guidelines for Screening Mutagenicity Testing Of Chemicals
- Version / remarks:
- (Chemical Substances Control Law of Japan)
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- 3-hydroxy-2-naphthoic acid
- EC Number:
- 202-180-8
- EC Name:
- 3-hydroxy-2-naphthoic acid
- Cas Number:
- 92-70-6
- Molecular formula:
- C11H8O3
- IUPAC Name:
- 3-hydroxy-2-naphthoic acid
- Details on test material:
- - Name of test material (as cited in study report): 3-hydroxy-2-naphthoic acid
- Analytical purity: 99.2%
- Impurities (identity and concentrations): no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: mouse/BDF1
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Mouse/BDF1 (C57BL/6 × DBA/2)[SPF] was used.
No additional details
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- - Vehicle(s)/solvent(s) used: 0.5 % Methylcellulose solution
No additional data - Details on exposure:
- PREPARATION OF DOSING SOLUTIONS:
no data - Duration of treatment / exposure:
- 2 consecutive days
- Frequency of treatment:
- daily
- Post exposure period:
- sampling was done 24 hours after the second dose
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 125, 250, 500 mg/kg
Basis:
actual ingested
- No. of animals per sex per dose:
- 5
- Control animals:
- yes, concurrent vehicle
- Positive control(s):
- mitomycin C
Examinations
- Tissues and cell types examined:
- bone marrow cells
- Details of tissue and slide preparation:
- no data
- Evaluation criteria:
- no data
- Statistics:
- no data
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Remarks:
- the test substance did not induce micronucleated erythrocytes in mouse bone marrow cells.
- Toxicity:
- yes
- Remarks:
- not specified; toxicity did not substantially differ between the sexes of mice.
- Vehicle controls validity:
- valid
- Negative controls validity:
- not specified
- Positive controls validity:
- valid
- Additional information on results:
- RESULTS OF RANGE-FINDING STUDY
1 male animal died in the group treated with 700 mg/kg in the dose-finding study.
RESULTS OF DEFINITIVE STUDY
No data
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
