3-hydroxy-2-naphthoic acid

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Abstract information in OECD SIDS report of 2004; study described in OECD SIDS as valid without restrictions.

Data source

Reference

Reference Type:

secondary source

Title:

Unnamed

Year:

2004

Report date:

2004

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

not specified

GLP compliance:

yes

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

3-hydroxy-2-naphthoic acid

EC Number:

202-180-8

EC Name:

3-hydroxy-2-naphthoic acid

Cas Number:

92-70-6

Molecular formula:

C11H8O3

IUPAC Name:

3-hydroxy-2-naphthoic acid

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

For lower doses, only females were treated.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

CMC (carboxymethyl cellulose)

Doses:

315; 500; 800; 1000; 1250 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

823 mg/kg bw

95% CL:

> 581 - < 1 070

Mortality:

Mortality occurred within 35-200 minutes after exposure.
1250 mg/kg: 5/5 (m), 4/5 (f)
1000 mg/kg: 3/5 (m), 3/5 (f)
800 mg/kg: 1/5 (m), 2/5 (f)
500 mg/kg: 2/5 (f)
315 mg/kg: 0/5 (f)

Clinical signs:

315, 500, 800 mg/kg bw: 10-30 minutes after application
reduced activity, prostrate and lateral positioning.
1000, 1250 mg/kg bw: reduced activity, prostrate and lateral positioning, accelerated breathing and closure of eyes. These signs were observed until the end of the day of application. Diarrhea was seen in all groups, beginning at 30 to 60 minutes after application.
All surviving animals were free of symptoms on day 1 after application.

Body weight:

There was no influence on body weight gain.

Gross pathology:

At necropsy, dark coloration of the liver was found in the high dose animals that had died, whereas light-coloured spots were seen in the livers of animals that died in the 500 and 800 mg/kg bw groups. Hyperemia and fluid were seen in the gastro-intestinal tracts. Animals that were killed at the end of the observation period were free of pathological changes.