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EC number: 254-875-0 | CAS number: 40292-82-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: There are some restriction concerning the method and the documentation of the results. The study is however suficient for endpoint evaluation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- occlusive application of 1 mL; 72 h reading is missing; observation period 8 days
- GLP compliance:
- no
Test material
- Reference substance name:
- Neodecanoyl chloride
- EC Number:
- 254-875-0
- EC Name:
- Neodecanoyl chloride
- Cas Number:
- 40292-82-8
- Molecular formula:
- C10H19ClO
- IUPAC Name:
- 2,2-dimethyloctanoyl chloride
- Details on test material:
- Neodecanoyl chloride from BASF AG, substance No. 77/807. Degree of purity not reported
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gaukler (breeder)
- Weight at study initiation: 2.78 -3.40 kg
ENVIRONMENTAL CONDITIONS
not reported
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 1 h/ 4 h
- Observation period:
- 8 days
- Number of animals:
- 2 per exposure period
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): with Lutrol (mild detergent) concentrated and Lutrol:water 1:1
SCORING SYSTEM: OECD/Draize scoring system
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 4 h exposure
- Time point:
- other: 24 - 48 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 d
- Remarks on result:
- other: hard and pergamentous necrosis observed, respectively; see table for details
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 4 h exposure
- Time point:
- other: 24 - 48 h
- Score:
- 1.5
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 1 h exposure
- Time point:
- other: 24 - 48 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 d
- Remarks on result:
- other: at necropsy, leather-like necrosis was observed in 1/2 animals; scaling
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 1 h exposure
- Time point:
- other: 24 - 48 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 d
Any other information on results incl. tables
Exposition: | 1 h | |||
Animal | Reading | Erythema | Edema | Comment |
1 | 24 h | 2 | 2 | |
2 | 24 h | 2 | 2 | |
1 | 48 h | 2 | 2 | |
2 | 48 h | 2 | 2 | |
1 | 5 d | 2 | 2 | scaling |
2 | 5 d | 2 | 2 | scaling |
1 | 8 d | 0 | 0 | scaling; at necropsy, leather-like necrosis was reported |
2 | 8 d | 0 | 0 | scaling |
mean | 24 - 48 h | 2.00 | 2.00 | |
Exposition: | 4 h | |||
Animal | Reading | Erythema | Edema | Comment |
1 | 24 h | 2 | 1 | erythema extending beyond the area of application |
2 | 24 h | 2 | 2 | erythema extending beyond the area of application |
1 | 48 h | 2 | 1 | erythema extending beyond the area of application |
2 | 48 h | 2 | 2 | erythema extending beyond the area of application |
1 | 5 d | 4 | 2 | hard necrosis, scaling |
2 | 5 d | 4 | 2 | pergamentous necrosis, scaling |
1 | 8 d | 0 | 1 | necrosis dropped, scar, scaling |
2 | 8 d | 4 | 2 | necrosis eaten, scar, scaling |
mean | 24 - 48 h | 2.00 | 1.50 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 1C (corrosive) based on GHS criteria
- Remarks:
- Migrated information
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