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Diss Factsheets
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EC number: 254-875-0 | CAS number: 40292-82-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study. Restriction: degree of purity not reported
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Neodecanoyl chloride
- EC Number:
- 254-875-0
- EC Name:
- Neodecanoyl chloride
- Cas Number:
- 40292-82-8
- Molecular formula:
- C10H19ClO
- IUPAC Name:
- 2,2-dimethyloctanoyl chloride
- Details on test material:
- Neodecanoyl chloride from BASF AG, substance No. 77/807. Degree of purity not reported.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- ANIMALS
Body weights: 200-220 g (m); 170-180 (f).
Fasting: overnight, 15 - 20 h before treatment.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- Dose volume: 10 ml/kg bw.
Concentration of TS: 10, 14.7, 21.5, and 31.6% - Doses:
- 1000, 1470, 2150, and 3160 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Observation period: 14 days.
Observations: signs of toxicity daily during the observation period. Animals were weighed 2 to 4, 7, and 13 days after treatment.
Examination: autopsy after sacrifice 14 days after treatment. - Statistics:
- Company-owned software was used to calculate male and female LD50 values, confidence intervals, slope factor and homogeneity.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 760 mg/kg bw
- 95% CL:
- 1 429 - 2 163
- Mortality:
- All deaths occurred within 1 day of dosing. The number of
deaths in each group was:
Dose level males females
-----------------------------------------
1000 mg/kg 1/5 0/5
1470 mg/kg 1/5 2/5
2150 mg/kg 3/5 3/5
3160 mg/kg 5/5 5/5
----------------------------------------- - Clinical signs:
- other: Signs of toxicity included lethargy, atony, abnormal agitation, abnormal positioning, convulsions, rough fur, dyspnea, and general poor condition at 1000 mg/kg bw. Additionally giddiness, reduced pain reflex, narcosis-like state, spastic gait at 1470 and
- Gross pathology:
- Animals that died during the study had distension of the GI tract with diarrheic gut contents. No changes were noted in animals that survived.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.