Registration Dossier
Registration Dossier
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EC number: 203-459-7 | CAS number: 107-07-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
No valid data available.
Effects on developmental toxicity
Description of key information
See discussion section.
Additional information
In NTP TR 275 a summary is given of reproductive toxicity studies (page 18):
Malformations and high rates of embryo mortality occurred when chick embryos were administered 2-chloroethanol at doses of 50 or 100 mg/kg (egg weight) at 0 or 96 hours of incubation (Verrett, 1974).
Fetotoxicity and maternal toxicity were produced when the compound was administered by gavage to pregnant Swiss CD-1 mice on days 4-12 of gestation (RTI, 1983a).
No effect on the mother or offspring occurred when 2-chloroethanol was administered in drinking water to Swiss CD-1 mice on days 6-16 of gestation. No teratogenic effects were noted in New Zealand white rabbits administered 2-chloroethanol intravenously at doses (36 mg/kg per day) that produced significant levels of fetotoxicity or maternal toxicity (RTI, 1983b).
Justification for classification or non-classification
Not classified. No valid data on fertility available. In developmental studies effects were only observed at maternal toxic levels.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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