2-chloroethanol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

November 1988- July 1989

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: Only an LD50 value is reported. No further details.

Data source

Reference

Reference Type:

publication

Title:

The international validation of a fixed-dose procedure as an alternative to the classical LD50 test.

Author:

Van den Heuvel, M.J., Clark, D.G., Fielder, R.J., Koundakjian, P.P., Oliver, G.J.A., Pelling, D. Tomlinson, N.J., Walker, A.P.

Year:

1990

Bibliographic source:

Fd Chem. Toxic. Vol. 28, No. 7, pp. 469-482

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Test guideline 2

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)

GLP compliance:

not specified

Test type:

other: standard acute method and draft fixed dose method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-chloroethanol

EC Number:

203-459-7

EC Name:

2-chloroethanol

Cas Number:

107-07-3

Molecular formula:

C2H5ClO

IUPAC Name:

2-chloroethan-1-ol

Details on test material:

2-chloroethyl alcohol

Test animals

Species:

rat

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

60 mg/kg bw

95% CL:

50 - 73

Remarks on result:

other: classical LD50

Applicant's summary and conclusion

Executive summary:

In an international study involving 33 laboratories in 11 countries, the acute oral toxicity to the rat of 20 substances and preparations was evaluated using a fixed-dose procedure and the results compared with those obtained for the test materials using the classical LD50 test. The LD50 for 2 -chloroethanol found in the standard study is 60 mg/kg bw/day.